Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4290263..4291044 Replicon chromosome
Accession NZ_CP089797
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00790

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY11_RS20820 Protein ID WP_000625911.1
Coordinates 4290263..4290754 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY11_RS20825 Protein ID WP_001271379.1
Coordinates 4290751..4291044 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY11_RS20795 (4285399) 4285399..4287837 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY11_RS20800 (4287847) 4287847..4288386 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY11_RS20805 (4288421) 4288421..4288711 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY11_RS20810 (4289298) 4289298..4289525 + 228 WP_001112992.1 hypothetical protein -
LUY11_RS20815 (4289800) 4289800..4290048 - 249 Protein_4073 IS481 family transposase -
LUY11_RS20820 (4290263) 4290263..4290754 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY11_RS20825 (4290751) 4290751..4291044 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY11_RS20830 (4291362) 4291362..4291583 + 222 WP_052939504.1 hypothetical protein -
LUY11_RS20835 (4291849) 4291849..4292724 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY11_RS20840 (4292721) 4292721..4293008 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY11_RS20845 (4293001) 4293001..4293183 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY11_RS20850 (4293203) 4293203..4293302 + 100 Protein_4080 hypothetical protein -
LUY11_RS20855 (4293350) 4293350..4293544 + 195 WP_223163373.1 hypothetical protein -
LUY11_RS20860 (4293839) 4293839..4294744 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4277241..4293183 15942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229430 WP_000625911.1 NZ_CP089797:c4290754-4290263 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229430 NZ_CP124471:3623593-3623811 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229430 WP_001271379.1 NZ_CP089797:c4291044-4290751 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229430 NZ_CP124471:3623193-3623567 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References