Detailed information of TA system TA229405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3617779..3618193
• Replicon: chromosome
• Accession: NZ_CP089795
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00813

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY22_RS17695
• Protein ID: WP_023203422.1
• Coordinates: 3617936..3618193 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3617779..3618111 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY22_RS17665	3613036..3613533	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY22_RS17670	3614294..3614998	-	705	Protein_3461	integrase core domain-containing protein	-
LUY22_RS17675	3615051..3615287	+	237	Protein_3462	SymE family type I addiction module toxin	-
LUY22_RS17680	3615432..3615710	-	279	WP_012664366.1	hypothetical protein	-
LUY22_RS17685	3616028..3616495	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY22_RS17690	3616588..3616863	-	276	WP_223163371.1	hypothetical protein	-
-	3617779..3618111	-	333	-	-	Antitoxin
LUY22_RS17695	3617936..3618193	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY22_RS17700	3618252..3618560	-	309	WP_232691283.1	hypothetical protein	-
LUY22_RS17705	3618579..3618986	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY22_RS17710	3619347..3619868	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3595803..3651766	55963
	-	flank	IS/Tn	-	-	3614294..3614575	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229405 WP_023203422.1 NZ_CP089795:3617936-3618193 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229405 NZ_CP124467:2130640-2130742 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 333 bp

>AT229405 NZ_CP089795:c3618111-3617779 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin