Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3816260..3816945 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag LVJ76_RS17975 Protein ID WP_003417998.1
Coordinates 3816535..3816945 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LVJ76_RS17970 Protein ID WP_003912220.1
Coordinates 3816260..3816538 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS17950 (LVJ76_17965) 3812249..3813850 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
LVJ76_RS17955 (LVJ76_17970) 3813867..3814571 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
LVJ76_RS17960 (LVJ76_17975) 3814689..3815255 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
LVJ76_RS17965 (LVJ76_17980) 3815317..3816204 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
LVJ76_RS17970 (LVJ76_17985) 3816260..3816538 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ76_RS17975 (LVJ76_17990) 3816535..3816945 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS17980 (LVJ76_17995) 3816978..3818714 - 1737 WP_003418002.1 cholesterol oxidase -
LVJ76_RS17985 (LVJ76_18000) 3818770..3819897 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
LVJ76_RS17990 (LVJ76_18005) 3819917..3821506 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T229264 WP_003417998.1 NZ_CP089781:3816535-3816945 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T229264 NZ_CP124424:c4903257-4903150 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT229264 WP_003912220.1 NZ_CP089781:3816260-3816538 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT229264 NZ_CP124424:4903305-4903371 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References