Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3761931..3762460 | Replicon | chromosome |
| Accession | NZ_CP089781 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1179 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | LVJ76_RS17720 | Protein ID | WP_003417760.1 |
| Coordinates | 3762203..3762460 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | LVJ76_RS17715 | Protein ID | WP_003417757.1 |
| Coordinates | 3761931..3762206 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ76_RS17680 (LVJ76_17695) | 3758504..3759193 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| LVJ76_RS17685 (LVJ76_17700) | 3759380..3759751 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| LVJ76_RS17690 (LVJ76_17705) | 3759649..3759867 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| LVJ76_RS17695 (LVJ76_17710) | 3759894..3760154 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| LVJ76_RS17700 (LVJ76_17715) | 3760269..3760658 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| LVJ76_RS17705 (LVJ76_17720) | 3760672..3760965 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| LVJ76_RS17710 (LVJ76_17725) | 3760962..3761807 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| LVJ76_RS17715 (LVJ76_17730) | 3761931..3762206 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| LVJ76_RS17720 (LVJ76_17735) | 3762203..3762460 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| LVJ76_RS17725 (LVJ76_17740) | 3762502..3763692 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| LVJ76_RS17730 (LVJ76_17745) | 3763809..3764177 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| LVJ76_RS17735 (LVJ76_17750) | 3764174..3764725 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| LVJ76_RS17740 (LVJ76_17755) | 3764732..3765313 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| LVJ76_RS17745 (LVJ76_17760) | 3765294..3765662 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| LVJ76_RS17750 (LVJ76_17765) | 3765640..3766032 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T229262 WP_003417760.1 NZ_CP089781:3762203-3762460 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T229262 NZ_CP124424:c4055792-4055574 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT229262 WP_003417757.1 NZ_CP089781:3761931-3762206 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT229262 NZ_CP124424:c4056192-4055818 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|