Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2353753..2354448 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag LVJ76_RS10995 Protein ID WP_003410811.1
Coordinates 2353753..2354187 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag LVJ76_RS11000 Protein ID WP_003410814.1
Coordinates 2354194..2354448 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS10985 (LVJ76_11005) 2349987..2352948 + 2962 Protein_2172 DEAD/DEAH box helicase -
LVJ76_RS10990 (LVJ76_11010) 2352941..2353774 + 834 WP_003899172.1 SWIM zinc finger family protein -
LVJ76_RS10995 (LVJ76_11015) 2353753..2354187 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS11000 (LVJ76_11020) 2354194..2354448 - 255 WP_003410814.1 antitoxin Antitoxin
LVJ76_RS11005 (LVJ76_11025) 2354464..2354721 - 258 WP_003410816.1 hypothetical protein -
LVJ76_RS11010 (LVJ76_11030) 2355668..2355964 + 297 WP_003410820.1 PE family protein -
LVJ76_RS11015 (LVJ76_11035) 2356020..2356751 + 732 WP_003900467.1 PPE family protein -
LVJ76_RS11020 (LVJ76_11040) 2357291..2358037 - 747 WP_003906749.1 proteasome subunit alpha -
LVJ76_RS11025 (LVJ76_11045) 2358034..2358909 - 876 WP_003411023.1 proteasome subunit beta -
LVJ76_RS11030 (LVJ76_11050) 2358906..2359100 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T229244 WP_003410811.1 NZ_CP089781:c2354187-2353753 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T229244 NZ_CP124424:c516406-516304 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT229244 WP_003410814.1 NZ_CP089781:c2354448-2354194 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT229244 NZ_CP124424:516266-516534 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References