Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 443579..444590 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name pezT Uniprot ID A0A655I6S7
Locus tag LVJ76_RS01930 Protein ID WP_003906352.1
Coordinates 443579..444172 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ76_RS01935 Protein ID WP_003401860.1
Coordinates 444201..444590 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS01910 (LVJ76_01920) 439228..440610 + 1383 WP_003898415.1 magnesium transporter -
LVJ76_RS01915 (LVJ76_01925) 440622..441656 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ76_RS01920 (LVJ76_01930) 441752..442435 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ76_RS01925 (LVJ76_01935) 442424..443554 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LVJ76_RS01930 (LVJ76_01940) 443579..444172 - 594 WP_003906352.1 zeta toxin family protein Toxin
LVJ76_RS01935 (LVJ76_01945) 444201..444590 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ76_RS01940 (LVJ76_01950) 444671..445875 - 1205 Protein_383 VWA domain-containing protein -
LVJ76_RS01945 (LVJ76_01955) 445881..446483 - 603 WP_003898417.1 SRPBCC family protein -
LVJ76_RS01950 (LVJ76_01960) 446497..447393 - 897 WP_003898418.1 MoxR family ATPase -
LVJ76_RS01955 (LVJ76_01965) 447390..447983 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ76_RS01960 (LVJ76_01970) 447980..448735 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21358.60 Da        Isoelectric Point: 10.6337

>T229208 WP_003906352.1 NZ_CP089781:c444172-443579 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDKSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T229208 NZ_CP124415:3488342-3488629 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT229208 WP_003401860.1 NZ_CP089781:c444590-444201 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT229208 NZ_CP124415:3488616-3488918 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A655I6S7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References