Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2192967..2193835 | Replicon | chromosome |
| Accession | NZ_CP089776 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1896 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | LVJ71_RS10255 | Protein ID | WP_010886136.1 |
| Coordinates | 2192967..2193344 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LVJ71_RS10260 | Protein ID | WP_003913306.1 |
| Coordinates | 2193386..2193835 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ71_RS10205 (LVJ71_10215) | 2188756..2189208 | - | 453 | WP_003899095.1 | lipoprotein | - |
| LVJ71_RS10210 (LVJ71_10220) | 2189272..2189673 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| LVJ71_RS10215 (LVJ71_10225) | 2189666..2189848 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| LVJ71_RS10220 (LVJ71_10230) | 2189962..2190312 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| LVJ71_RS10225 (LVJ71_10235) | 2190323..2191225 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ71_RS10230 (LVJ71_10240) | 2191246..2191437 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ71_RS10235 (LVJ71_10245) | 2191438..2191734 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ71_RS10240 (LVJ71_10250) | 2191974..2192189 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ71_RS10245 (LVJ71_10255) | 2192186..2192497 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ71_RS10250 (LVJ71_10260) | 2192471..2192992 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ71_RS10255 (LVJ71_10265) | 2192967..2193344 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| LVJ71_RS10260 (LVJ71_10270) | 2193386..2193835 | + | 450 | WP_003913306.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| LVJ71_RS10265 (LVJ71_10275) | 2193832..2194377 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ71_RS10270 (LVJ71_10280) | 2194266..2194880 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ71_RS10275 (LVJ71_10285) | 2194929..2195225 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LVJ71_RS10280 (LVJ71_10290) | 2195222..2195473 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| LVJ71_RS10285 (LVJ71_10295) | 2195460..2195954 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ71_RS10290 (LVJ71_10300) | 2196114..2196521 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ71_RS10295 (LVJ71_10305) | 2196525..2196797 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ71_RS10300 (LVJ71_10310) | 2196830..2198050 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T228934 WP_010886136.1 NZ_CP089776:2192967-2193344 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T228934 NZ_CP124356:139578-139994 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16776.16 Da Isoelectric Point: 8.0771
>AT228934 WP_003913306.1 NZ_CP089776:2193386-2193835 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVS
Download Length: 450 bp
>AT228934 NZ_CP124356:139351-139581 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|