Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 709186..709829 Replicon chromosome
Accession NZ_CP089776
Organism Mycobacterium tuberculosis strain 02-R1896

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ71_RS03225 Protein ID WP_003403187.1
Coordinates 709428..709829 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ71_RS03220 Protein ID WP_003403184.1
Coordinates 709186..709431 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ71_RS03185 (LVJ71_03180) 704466..704996 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ71_RS03190 (LVJ71_03185) 704980..705675 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ71_RS03195 (LVJ71_03190) 705798..706109 + 312 WP_003403164.1 hypothetical protein -
LVJ71_RS03200 (LVJ71_03195) 706181..707131 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ71_RS03205 (LVJ71_03200) 707372..707956 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ71_RS03210 (LVJ71_03205) 707958..708668 + 711 Protein_636 IS607 family element RNA-guided endonuclease TnpB -
LVJ71_RS03215 (LVJ71_03210) 708671..709141 + 471 WP_003898523.1 hypothetical protein -
LVJ71_RS03220 (LVJ71_03215) 709186..709431 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ71_RS03225 (LVJ71_03220) 709428..709829 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ71_RS03230 (LVJ71_03225) 709820..709999 + 180 Protein_640 hypothetical protein -
LVJ71_RS03235 (LVJ71_03230) 710417..710614 - 198 WP_003403191.1 hypothetical protein -
LVJ71_RS03240 (LVJ71_03235) 710694..711851 - 1158 WP_003912926.1 hypothetical protein -
LVJ71_RS03245 (LVJ71_03240) 711903..712124 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ71_RS03250 (LVJ71_03245) 712266..712871 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T228911 WP_003403187.1 NZ_CP089776:709428-709829 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T228911 NZ_CP124355:866769-867143 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT228911 WP_003403184.1 NZ_CP089776:709186-709431 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT228911 NZ_CP124355:866312-866680 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References