Detailed information of TA system TA022891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 1859192..1860213
• Replicon: chromosome
• Accession: NC_010725
• Organism: Methylobacterium populi BJ001

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: MPOP_RS08630
• Protein ID: WP_012453636.1
• Coordinates: 1859192..1859689 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: B1ZHF4
• Locus tag: MPOP_RS08635
• Protein ID: WP_012453637.1
• Coordinates: 1859686..1860213 (-)
• Length: 176 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPOP_RS08610	1855354..1855905	+	552	WP_012453632.1	alpha/beta hydrolase	-
MPOP_RS08615	1856105..1856491	+	387	WP_012453633.1	hypothetical protein	-
MPOP_RS08620	1856606..1857640	-	1035	WP_012453634.1	TIGR01620 family protein	-
MPOP_RS08625	1857637..1859085	-	1449	WP_012453635.1	YcjX family protein	-
MPOP_RS08630	1859192..1859689	-	498	WP_012453636.1	RES family NAD+ phosphorylase	Toxin
MPOP_RS08635	1859686..1860213	-	528	WP_012453637.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
MPOP_RS08640	1860289..1863651	-	3363	WP_012453638.1	PAS domain-containing protein	-
MPOP_RS08645	1863648..1865108	-	1461	WP_012453639.1	O-antigen ligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-151)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (130-172)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 17755.05 Da
• Isoelectric Point: 4.9201

>T22891 WP_012453636.1 NC_010725:c1859689-1859192 [Methylorubrum populi BJ001]
VSRSLWRIGTDARSYTADDMSGTGAKLSGGRWNDVGVALVYAAGSRALACLETFVHLNAGGLPLNRYLVEIDVPDDVWAS
AEVATPDTLPVGWDAEPAGLVSLAFGTDWANGNRSALLLVPSVIVPEEQNALINPAHPDAAKITARKVRKWLYDPRLDRD
RLSFA

Nucleotide

• Length: 498 bp

>T22891 NC_010725:c1859689-1859192 [Methylorubrum populi BJ001]
GTGAGCCGGTCGCTGTGGCGGATCGGGACGGACGCCCGGTCCTACACCGCCGACGATATGTCGGGGACCGGCGCCAAGCT
CTCCGGCGGTCGCTGGAACGACGTCGGAGTCGCGCTGGTCTACGCGGCGGGCAGCCGGGCCCTCGCCTGCCTCGAAACCT
TCGTCCACCTCAATGCCGGCGGCCTGCCGCTGAACCGGTACCTCGTCGAGATCGACGTGCCGGACGACGTCTGGGCGTCG
GCCGAGGTCGCAACGCCGGACACCCTGCCCGTCGGCTGGGATGCCGAGCCGGCGGGCCTCGTCAGCCTTGCCTTCGGCAC
GGACTGGGCGAACGGAAACCGGTCGGCGCTCCTGCTGGTCCCCTCCGTCATCGTCCCGGAGGAACAGAACGCCCTCATCA
ATCCCGCCCATCCCGACGCGGCGAAGATCACGGCGCGCAAGGTCCGGAAGTGGCTCTACGACCCGCGCCTCGACCGAGAC
CGGCTTTCGTTCGCGTGA

Antitoxin

Protein

• Length: 176 a.a.
• Molecular weight: 18762.45 Da
• Isoelectric Point: 9.4633

>AT22891 WP_012453637.1 NC_010725:c1860213-1859686 [Methylorubrum populi BJ001]
MTDTTAKAVIKRRKSRGPDAPSGTHPGAHPGARPFAYLDLYRASPFDRIEVIKAGVPARTVKGFITALHLDQQVMFDALN
LKTATVNKKAARDEALSAEDSERVVGLAKLVGQLEAMIQESGTAQDFDAPGWLSRWLREPLPALGGGKPLDLLDTMEGQA
LVSRALAQIQSGAYA

Nucleotide

• Length: 528 bp

>AT22891 NC_010725:c1860213-1859686 [Methylorubrum populi BJ001]
ATGACGGATACGACGGCCAAGGCCGTGATCAAGCGGAGGAAGTCGCGCGGTCCCGATGCGCCTTCCGGCACGCATCCCGG
TGCACATCCCGGCGCGCGGCCCTTCGCCTATCTCGATCTCTACCGCGCCTCACCCTTCGACCGCATCGAGGTCATCAAAG
CCGGGGTTCCAGCCCGGACGGTCAAGGGCTTCATCACCGCGCTGCATCTCGACCAGCAAGTGATGTTCGATGCCCTCAAC
CTGAAGACGGCCACGGTGAACAAGAAGGCGGCGAGGGACGAGGCCCTCTCGGCCGAGGACAGCGAGCGGGTCGTCGGCCT
CGCCAAGCTGGTCGGGCAGCTCGAAGCGATGATCCAGGAATCCGGCACCGCGCAGGATTTCGACGCGCCGGGCTGGCTAT
CGCGCTGGCTGCGCGAGCCCCTGCCGGCGCTGGGCGGCGGCAAGCCGCTCGACCTCCTCGACACGATGGAAGGCCAAGCT
CTGGTGTCGCGCGCGTTGGCGCAGATCCAGAGCGGAGCCTATGCGTGA

Structures

Antitoxin

• AlphaFold DB: B1ZHF4