Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 448734..449745 Replicon chromosome
Accession NZ_CP089773
Organism Mycobacterium tuberculosis strain 01-R1430

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag LVJ68_RS01945 Protein ID WP_003401859.1
Coordinates 448734..449327 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag LVJ68_RS01950 Protein ID WP_003401860.1
Coordinates 449356..449745 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ68_RS01925 (LVJ68_01925) 444383..445765 + 1383 WP_003898415.1 magnesium transporter -
LVJ68_RS01930 (LVJ68_01930) 445777..446811 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
LVJ68_RS01935 (LVJ68_01935) 446907..447590 + 684 WP_003401857.1 VTT domain-containing protein -
LVJ68_RS01940 (LVJ68_01940) 447579..448709 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
LVJ68_RS01945 (LVJ68_01945) 448734..449327 - 594 WP_003401859.1 zeta toxin family protein Toxin
LVJ68_RS01950 (LVJ68_01950) 449356..449745 - 390 WP_003401860.1 hypothetical protein Antitoxin
LVJ68_RS01955 (LVJ68_01955) 449826..451037 - 1212 WP_003906353.1 VWA domain-containing protein -
LVJ68_RS01960 (LVJ68_01960) 451043..451645 - 603 WP_003898417.1 SRPBCC family protein -
LVJ68_RS01965 (LVJ68_01965) 451659..452555 - 897 WP_003898418.1 MoxR family ATPase -
LVJ68_RS01970 (LVJ68_01970) 452552..453145 - 594 WP_003401864.1 NTP transferase domain-containing protein -
LVJ68_RS01975 (LVJ68_01975) 453142..453897 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T228723 WP_003401859.1 NZ_CP089773:c449327-448734 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T228723 NZ_CP124339:2012163-2012414 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT228723 WP_003401860.1 NZ_CP089773:c449745-449356 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT228723 NZ_CP124339:2012411-2012665 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References