Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3080367..3081054 | Replicon | chromosome |
| Accession | NZ_CP089610 | ||
| Organism | Mycobacterium tuberculosis strain I0004290-8 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | LVJ91_RS14620 | Protein ID | WP_003414064.1 |
| Coordinates | 3080659..3081054 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | LVJ91_RS14615 | Protein ID | WP_003414061.1 |
| Coordinates | 3080367..3080633 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ91_RS14590 (LVJ91_14595) | 3076006..3076908 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| LVJ91_RS14595 (LVJ91_14600) | 3076977..3077729 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| LVJ91_RS14600 (LVJ91_14610) | 3077973..3078248 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| LVJ91_RS14605 (LVJ91_14615) | 3078245..3079867 | - | 1623 | WP_003906897.1 | class I SAM-dependent DNA methyltransferase | - |
| LVJ91_RS14610 (LVJ91_14620) | 3079954..3080370 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| LVJ91_RS14615 (LVJ91_14625) | 3080367..3080633 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LVJ91_RS14620 (LVJ91_14630) | 3080659..3081054 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LVJ91_RS14625 (LVJ91_14635) | 3081051..3081320 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LVJ91_RS14630 (LVJ91_14640) | 3081330..3082424 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| LVJ91_RS14635 (LVJ91_14645) | 3082421..3082840 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| LVJ91_RS14640 (LVJ91_14650) | 3082839..3082913 | + | 75 | Protein_2889 | hypothetical protein | - |
| LVJ91_RS14645 (LVJ91_14655) | 3082914..3083393 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| LVJ91_RS14650 (LVJ91_14660) | 3083464..3084264 | - | 801 | WP_009939104.1 | thymidylate synthase | - |
| LVJ91_RS14655 (LVJ91_14665) | 3084420..3085157 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T228490 WP_003414064.1 NZ_CP089610:c3081054-3080659 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T228490 NZ_CP123983:1042128-1042277 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT228490 WP_003414061.1 NZ_CP089610:c3080633-3080367 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT228490 NZ_CP123983:1041506-1042105 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|