Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2264151..2264777 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag LVJ91_RS10590 Protein ID WP_003410075.1
Coordinates 2264379..2264777 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag LVJ91_RS10585 Protein ID WP_003911750.1
Coordinates 2264151..2264378 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS10575 (LVJ91_10590) 2262190..2262534 - 345 WP_003410065.1 ferredoxin family protein -
LVJ91_RS10580 (LVJ91_10595) 2262723..2263892 - 1170 WP_003899126.1 ATP-binding protein -
LVJ91_RS10585 (LVJ91_10600) 2264151..2264378 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ91_RS10590 (LVJ91_10605) 2264379..2264777 + 399 WP_003410075.1 PIN domain nuclease Toxin
LVJ91_RS10595 (LVJ91_10610) 2264960..2265391 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
LVJ91_RS10600 (LVJ91_10615) 2265492..2265926 + 435 WP_003914358.1 DUF1398 domain-containing protein -
LVJ91_RS10605 (LVJ91_10620) 2266363..2266542 - 180 Protein_2096 hypothetical protein -
LVJ91_RS10610 (LVJ91_10625) 2266630..2267250 + 621 WP_003410086.1 IS110 family transposase -
LVJ91_RS10615 (LVJ91_10630) 2267204..2267794 + 591 WP_003899131.1 IS110 family transposase -
LVJ91_RS10620 (LVJ91_10635) 2267922..2268296 - 375 Protein_2099 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T228477 WP_003410075.1 NZ_CP089610:2264379-2264777 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T228477 NZ_CP123967:1745213-1745458 [Tessaracoccus sp. T21]
ATGCTGTTGGTGTGGGACCAGAACGCCTCGGAAGACTACCTCTGGTGGCAGACACAGGACCGCCGGGTCCTCAAACGCAT
CAGCACCCTCATCCAGGACGTCTCCCGCAACGGCAACGAGGGACTCGGAAAGCCGGAGGCCCTCAGGCACGACTTCGCCG
GCTACTGGTCACGCCGCATCACCGAGGAGCATCGCCTCGTCCACAAGATCGTCGGCGATGAAATCCGGATCGCAGCCTGC
CGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT228477 WP_003911750.1 NZ_CP089610:2264151-2264378 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT228477 NZ_CP123967:1744956-1745210 [Tessaracoccus sp. T21]
ATGAAGACGATGAGCTACACGGAGTCCCGGGCACGCTACGCCGAGGTTCTCGATTCTGTCGTTGATGACCGGGAGGAGGT
CGTCATCACCCGAGCGGGCCACGACCCGGTGGTCATCGTCTCCCTGGACGAGTACGAGGCCCTCAAAGAGACCGCCTACC
TCCTGCGCTCTCCCGCAAACGCCCGGCGCCTTCTCGACGCGATGGAGCGGCTGGAGGGCGGCCGCGGCGACCCCCACGAC
CTGACCGCCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References