Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1580540..1581195 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag LVJ91_RS07460 Protein ID WP_003898861.1
Coordinates 1580540..1580941 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LVJ91_RS07465 Protein ID WP_003407272.1
Coordinates 1580938..1581195 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS07445 (LVJ91_07450) 1576118..1577503 - 1386 WP_003407260.1 cytochrome P450 -
LVJ91_RS07450 (LVJ91_07455) 1577581..1578615 + 1035 WP_003407264.1 AraC family transcriptional regulator -
LVJ91_RS07455 (LVJ91_07460) 1578661..1580285 - 1625 Protein_1468 PE family protein -
LVJ91_RS07460 (LVJ91_07465) 1580540..1580941 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ91_RS07465 (LVJ91_07470) 1580938..1581195 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
LVJ91_RS07470 (LVJ91_07475) 1581278..1582237 - 960 WP_003407276.1 alpha/beta hydrolase -
LVJ91_RS07475 (LVJ91_07480) 1582262..1583224 - 963 WP_003407279.1 alpha/beta hydrolase -
LVJ91_RS07480 (LVJ91_07485) 1583223..1583960 + 738 WP_031647000.1 lysoplasmalogenase -
LVJ91_RS07485 (LVJ91_07490) 1584041..1586008 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T228466 WP_003898861.1 NZ_CP089610:c1580941-1580540 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T228466 NZ_CP123963:2012679-2012782 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT228466 WP_003407272.1 NZ_CP089610:c1581195-1580938 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT228466 NZ_CP123963:c2012820-2012549 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References