Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 719567..720216 Replicon chromosome
Accession NZ_CP089610
Organism Mycobacterium tuberculosis strain I0004290-8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LVJ91_RS03285 Protein ID WP_070894418.1
Coordinates 719821..720216 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag LVJ91_RS03280 Protein ID WP_003403235.1
Coordinates 719567..719821 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ91_RS03255 (LVJ91_03250) 714693..714776 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
LVJ91_RS03260 (LVJ91_03255) 714795..715876 + 1082 Protein_646 galactose-1-phosphate uridylyltransferase -
LVJ91_RS03265 (LVJ91_03260) 715873..716964 + 1092 WP_057951135.1 galactokinase -
LVJ91_RS03270 (LVJ91_03265) 717359..718423 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ91_RS03275 (LVJ91_03270) 718527..719474 + 948 WP_003403232.1 DUF732 domain-containing protein -
LVJ91_RS03280 (LVJ91_03275) 719567..719821 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
LVJ91_RS03285 (LVJ91_03280) 719821..720216 + 396 WP_070894418.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
LVJ91_RS03290 (LVJ91_03285) 720310..721050 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
LVJ91_RS03295 (LVJ91_03290) 721182..721442 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ91_RS03300 (LVJ91_03295) 721439..721846 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
LVJ91_RS03305 (LVJ91_03300) 721918..723069 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
LVJ91_RS03310 (LVJ91_03305) 723162..724889 - 1728 WP_070891611.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14234.00 Da        Isoelectric Point: 4.7475

>T228451 WP_070894418.1 NZ_CP089610:719821-720216 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGREPDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T228451 NZ_CP123958:771461-771793 [Mannheimia haemolytica]
ATGAAACGTGGCGATATTTACTGGCTCGATCTTGATCCAACCTTAGGACACGAACAATCAGGCTTCCGCCCCGTTGTAAT
TGTTTCCGCAACTGCATTTAATCTAGCCAGTAAACTGCCTGTGGTTGTGCCGATTACTAACGGTGGAGCTTTTGCTGAAA
GACTGGGCTTTGCCGTTTCATTAAAAGATGCCGGCTTAAAAACAACAGGGATTATTCGATGCGATCAACCTCGCACAGTC
GATATTGCACAACGCCATGGAAAATTTATCGAAGCCTTACCCGAAAGCCTACTTGATGAAATTATGGCAAGGGTTTCAGT
GATTTTTGAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT228451 WP_003403235.1 NZ_CP089610:719567-719821 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT228451 NZ_CP123958:771204-771464 [Mannheimia haemolytica]
ATGCCAACAATCGCATTACGTCAGGTCGGTGGCTCGGTTGCAATGGTGATTCCGCCTGCTTTTTTAGAGGCACTCAAGCT
CTCCGTCGGTAGCAAAGTGGATTTGTCTTTAAACGACAACCAACTCGTGATTAATCCTGCCCGCCCAAAAGTGAAATACA
GCTTAGAGGAATTATTAAGACAATCCGATTTTGAGGCAGCAAGGAATGAAGAAAGCCAATCGTGGTTATCCGAGCCGGCA
ATAGGAAAAGAAATTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References