Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 92446..93243 | Replicon | chromosome |
| Accession | NZ_CP089586 | ||
| Organism | Staphylococcus aureus strain E1185_IV_ST12 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | LUU82_RS00520 | Protein ID | WP_000525008.1 |
| Coordinates | 92446..92907 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | LUU82_RS00525 | Protein ID | WP_001260487.1 |
| Coordinates | 92920..93243 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUU82_RS00495 (88182) | 88182..88712 | + | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
| LUU82_RS00500 (88972) | 88972..90117 | - | 1146 | WP_209168377.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| LUU82_RS00505 (90162) | 90162..91208 | - | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| LUU82_RS00510 (91278) | 91278..91748 | - | 471 | WP_000183249.1 | hypothetical protein | - |
| LUU82_RS00515 (91741) | 91741..92262 | - | 522 | WP_001102444.1 | hypothetical protein | - |
| LUU82_RS00520 (92446) | 92446..92907 | - | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| LUU82_RS00525 (92920) | 92920..93243 | - | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LUU82_RS00530 (93407) | 93407..93655 | + | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| LUU82_RS00535 (93668) | 93668..94111 | + | 444 | WP_000435356.1 | hypothetical protein | - |
| LUU82_RS00540 (94126) | 94126..94305 | + | 180 | WP_000393082.1 | hypothetical protein | - |
| LUU82_RS00545 (94295) | 94295..94534 | - | 240 | WP_000438628.1 | hypothetical protein | - |
| LUU82_RS00550 (94591) | 94591..95382 | + | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| LUU82_RS00555 (95383) | 95383..95607 | + | 225 | WP_000187184.1 | hypothetical protein | - |
| LUU82_RS00560 (95647) | 95647..96096 | + | 450 | WP_000993183.1 | hypothetical protein | - |
| LUU82_RS00565 (96110) | 96110..96325 | + | 216 | WP_025175692.1 | hypothetical protein | - |
| LUU82_RS00570 (96318) | 96318..96479 | + | 162 | WP_000048124.1 | DUF1270 family protein | - |
| LUU82_RS00575 (96572) | 96572..96874 | + | 303 | WP_000163430.1 | DUF2482 family protein | - |
| LUU82_RS00580 (96879) | 96879..97139 | + | 261 | WP_000291481.1 | DUF1108 family protein | - |
| LUU82_RS00585 (97149) | 97149..97400 | + | 252 | WP_000683290.1 | hypothetical protein | - |
| LUU82_RS00590 (97393) | 97393..97926 | + | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 90162..131149 | 40987 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T228372 WP_000525008.1 NZ_CP089586:c92907-92446 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T228372 NZ_CP123853:2691965-2692327 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT228372 WP_001260487.1 NZ_CP089586:c93243-92920 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT228372 NZ_CP123853:2691798-2691968 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|