Detailed information of TA system TA228324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4756887..4757706
• Replicon: chromosome
• Accession: NZ_CP089448
• Organism: Klebsiella michiganensis strain 8-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: LT930_RS22445
• Protein ID: WP_004110819.1
• Coordinates: 4757449..4757706 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: LT930_RS22440
• Protein ID: WP_185219606.1
• Coordinates: 4756887..4757438 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LT930_RS22420 (LT930_22420)	4752258..4753655	+	1398	WP_014228060.1	MFS transporter	-
LT930_RS22425 (LT930_22425)	4753778..4755118	+	1341	WP_103815323.1	carbohydrate porin	-
LT930_RS22430 (LT930_22430)	4755241..4755987	-	747	WP_224227290.1	class I SAM-dependent methyltransferase	-
LT930_RS22435 (LT930_22435)	4756411..4756773	-	363	Protein_4412	class I SAM-dependent methyltransferase	-
LT930_RS22440 (LT930_22440)	4756887..4757438	-	552	WP_185219606.1	N-acetyltransferase	Antitoxin
LT930_RS22445 (LT930_22445)	4757449..4757706	-	258	WP_004110819.1	YjhX family toxin	Toxin
LT930_RS22450 (LT930_22450)	4758382..4759566	+	1185	WP_014228054.1	mannonate dehydratase	-
LT930_RS22455 (LT930_22455)	4759640..4761115	+	1476	WP_064407195.1	fructuronate reductase	-
LT930_RS22460 (LT930_22460)	4761254..4762030	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T228324 WP_004110819.1 NZ_CP089448:c4757706-4757449 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T228324 NZ_CP123767:34004-34291 [Acinetobacter pittii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCGCATTCCCAAGAATAAGCTCCCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTATTTTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19976.78 Da
• Isoelectric Point: 6.4897

>AT228324 WP_185219606.1 NZ_CP089448:c4757438-4756887 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHSIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRAGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT228324 NZ_CP123767:33766-34014 [Acinetobacter pittii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATATACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2