Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2932068..2932899 Replicon chromosome
Accession NZ_CP089445
Organism Escherichia coli strain 5-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag LT922_RS14625 Protein ID WP_000854815.1
Coordinates 2932525..2932899 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag LT922_RS14620 Protein ID WP_001280918.1
Coordinates 2932068..2932436 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT922_RS14575 (2927157) 2927157..2927903 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
LT922_RS14580 (2927986) 2927986..2928336 + 351 Protein_2852 hypothetical protein -
LT922_RS14585 (2928352) 2928352..2928762 + 411 WP_000846703.1 hypothetical protein -
LT922_RS14590 (2928983) 2928983..2929801 + 819 WP_001542275.1 DUF932 domain-containing protein -
LT922_RS14595 (2929801) 2929801..2930046 + 246 WP_001164966.1 hypothetical protein -
LT922_RS14600 (2930140) 2930140..2930613 + 474 WP_001542276.1 antirestriction protein -
LT922_RS14605 (2930629) 2930629..2931105 + 477 WP_001186200.1 RadC family protein -
LT922_RS14610 (2931168) 2931168..2931389 + 222 WP_000692345.1 DUF987 domain-containing protein -
LT922_RS14615 (2931408) 2931408..2932052 + 645 WP_000086752.1 hypothetical protein -
LT922_RS14620 (2932068) 2932068..2932436 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LT922_RS14625 (2932525) 2932525..2932899 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
LT922_RS14630 (2932896) 2932896..2933090 + 195 WP_000988600.1 DUF5983 family protein -
LT922_RS14635 (2933136) 2933136..2933216 + 81 Protein_2863 hypothetical protein -
LT922_RS14640 (2933505) 2933505..2933585 - 81 WP_023441679.1 hypothetical protein -
LT922_RS14645 (2933564) 2933564..2933887 + 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
LT922_RS14650 (2933988) 2933988..2934317 - 330 WP_000450409.1 DUF496 family protein -
LT922_RS14655 (2934489) 2934489..2935547 - 1059 WP_001200889.1 FUSC family protein -
LT922_RS14660 (2935745) 2935745..2936218 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
LT922_RS14665 (2936337) 2936337..2937503 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T228295 WP_000854815.1 NZ_CP089445:2932525-2932899 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T228295 NZ_CP123642:4390835-4391182 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGTTGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT228295 WP_001280918.1 NZ_CP089445:2932068-2932436 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT228295 NZ_CP123642:4391182-4391481 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCAGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References