Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3693882..3694479 Replicon chromosome
Accession NZ_CP089441
Organism Klebsiella quasipneumoniae strain GLW9C22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LT990_RS17940 Protein ID WP_087827241.1
Coordinates 3694162..3694479 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LT990_RS17935 Protein ID WP_049013658.1
Coordinates 3693882..3694169 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT990_RS17905 (3690070) 3690070..3690318 + 249 WP_002893037.1 DUF1158 domain-containing protein -
LT990_RS17910 (3690336) 3690336..3690677 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
LT990_RS17915 (3690708) 3690708..3691823 - 1116 WP_074423618.1 MBL fold metallo-hydrolase -
LT990_RS17920 (3692003) 3692003..3692587 + 585 WP_023288732.1 TetR/AcrR family transcriptional regulator -
LT990_RS17925 (3692584) 3692584..3692952 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
LT990_RS17930 (3693072) 3693072..3693725 + 654 WP_023288731.1 oxygen-insensitive NAD(P)H nitroreductase -
LT990_RS17935 (3693882) 3693882..3694169 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
LT990_RS17940 (3694162) 3694162..3694479 - 318 WP_087827241.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT990_RS17945 (3694664) 3694664..3695707 - 1044 WP_101989644.1 DUF2157 domain-containing protein -
LT990_RS17950 (3696223) 3696223..3697089 - 867 WP_032454966.1 helix-turn-helix transcriptional regulator -
LT990_RS17955 (3697198) 3697198..3698625 + 1428 WP_087827239.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12049.33 Da        Isoelectric Point: 10.9540

>T228266 WP_087827241.1 NZ_CP089441:c3694479-3694162 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEICLALKRLEEMRNE

Download         Length: 318 bp

>T228266 NZ_CP123598:1857988-1858275 [Enterobacter cloacae]
ATGCCAACGGAGTATGAGTGGGATAGCGATAAGGCGAAAAGTAACCAGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TTTGGTTTTCGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAGAACGGTGAGTTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGCGTCATTATTATCCTGGTCGCACATACGGTACGTTTCGAAAGCGGAGGCGAAATTATTCGTATCATTAGC
GCACGTAAGGCGGACCGTAAAGAGAGGAGCCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT228266 WP_049013658.1 NZ_CP089441:c3694169-3693882 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT228266 NZ_CP123598:1858262-1858564 [Enterobacter cloacae]
ATGAGCATCGTTAAACATAAACGAGGTAGTTCGCCTGAGGTTAGCGCTCGTCGTGACGCTGAGCTAAAAGCATTAGCTGA
AAAAACAGAAGCAGAAATCGATTACAGCGATATTCCTGCCACGGACGATAAACAGTGGTCCGGGGCGGTGCGAGGGAAGT
TCTATCGGCCACTTAAAACGCAGGCATCTGTACGCATTGACGCCGACGTGATGGAGTGGCTGAAACGGCCTGGAAAGGGT
TACCAGACGCGGCTAAACGCCATATTGCGTGAAGCGATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References