Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3125..3647 Replicon plasmid pHN21SC92-3
Accession NZ_CP089440
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag LT980_RS26980 Protein ID WP_000220560.1
Coordinates 3366..3647 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag LT980_RS26975 Protein ID WP_000121743.1
Coordinates 3125..3376 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS26960 (LT980_26950) 57..410 - 354 WP_000876434.1 DNA distortion polypeptide 3 -
LT980_RS26965 (LT980_26955) 547..993 - 447 WP_001074386.1 hypothetical protein -
LT980_RS26970 (LT980_26960) 1033..1869 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
LT980_RS26975 (LT980_26965) 3125..3376 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
LT980_RS26980 (LT980_26970) 3366..3647 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT980_RS26985 (LT980_26975) 3793..4116 + 324 WP_001181903.1 hypothetical protein -
LT980_RS26990 (LT980_26980) 4161..4406 + 246 WP_000356546.1 hypothetical protein -
LT980_RS26995 (LT980_26985) 4396..4611 + 216 WP_001180116.1 hypothetical protein -
LT980_RS27000 (LT980_26990) 4704..5033 + 330 WP_000866648.1 hypothetical protein -
LT980_RS27005 (LT980_26995) 5320..5469 + 150 WP_000003880.1 hypothetical protein -
LT980_RS27010 (LT980_27000) 5482..5754 + 273 WP_000160399.1 hypothetical protein -
LT980_RS27015 (LT980_27005) 6081..6626 + 546 WP_038976855.1 DNA distortion polypeptide 1 -
LT980_RS27020 (LT980_27010) 6629..7786 + 1158 WP_000538023.1 DNA distortion polypeptide 2 -
LT980_RS27025 (LT980_27015) 8147..8638 + 492 WP_000872475.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / qnrS1 / dfrA5 / tet(A) / blaTEM-1B - 1..48371 48371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T228253 WP_000220560.1 NZ_CP089440:3366-3647 [Citrobacter portucalensis]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T228253 NZ_CP123597:c3020207-3019818 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCGTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAACATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT228253 WP_000121743.1 NZ_CP089440:3125-3376 [Citrobacter portucalensis]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT228253 NZ_CP123597:c3020474-3020211 [Serratia marcescens]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCAC
GATCCCTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References