Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 94110..95733 Replicon plasmid pHN21SC92-2
Accession NZ_CP089439
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name hipA Uniprot ID C1IUI3
Locus tag LT980_RS26155 Protein ID WP_000088044.1
Coordinates 94408..95733 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A6M3PBR7
Locus tag LT980_RS26150 Protein ID WP_012477377.1
Coordinates 94110..94403 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS26130 (LT980_26120) 89909..90301 + 393 WP_000341066.1 hypothetical protein -
LT980_RS26135 (LT980_26125) 90960..91616 + 657 WP_000462754.1 trypsin-like serine protease -
LT980_RS26140 (LT980_26130) 91819..92316 + 498 WP_000340139.1 membrane protein -
LT980_RS26145 (LT980_26135) 92321..93709 + 1389 WP_012695445.1 hypothetical protein -
LT980_RS26150 (LT980_26140) 94110..94403 + 294 WP_012477377.1 helix-turn-helix transcriptional regulator Antitoxin
LT980_RS26155 (LT980_26145) 94408..95733 + 1326 WP_000088044.1 type II toxin-antitoxin system HipA family toxin Toxin
LT980_RS26160 (LT980_26150) 95794..96000 + 207 WP_000134171.1 hypothetical protein -
LT980_RS26165 (LT980_26155) 96101..96511 + 411 WP_000985909.1 hypothetical protein -
LT980_RS26170 (LT980_26160) 96524..97048 + 525 WP_001805097.1 hypothetical protein -
LT980_RS26175 (LT980_26165) 97230..97844 - 615 Protein_94 IS110-like element IS4321 family transposase -
LT980_RS26180 (LT980_26170) 97900..98868 - 969 WP_250671244.1 IS5 family transposase -
LT980_RS26185 (LT980_26175) 98901..99299 - 399 Protein_96 IS110 family transposase -
LT980_RS26190 (LT980_26180) 99390..99824 - 435 WP_000405672.1 Cd(II)/Pb(II)-responsive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / mcr-9 / mph(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / dfrA19 / floR / sul2 / ere(A) / aac(6')-IIc - 1..231384 231384


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.32 Da        Isoelectric Point: 6.5044

>T228252 WP_000088044.1 NZ_CP089439:94408-95733 [Citrobacter portucalensis]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T228252 NZ_CP123597:c2578074-2577733 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGAAAAAGGGCCCGGCTTGCCCAGGCCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGCGCCGTGGCGAACCGTTGCGGGCATTTTTCGCCTTCGATCCGTACCGCGTCGGCATG
GTGCTTTGCGCGGGCAATAAAAAACGTTTTTACGATCGAATGCTGCAGATTGTCGATCGGGAATTCACGAATTGGCTGAA
CACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10860.30 Da        Isoelectric Point: 10.3134

>AT228252 WP_012477377.1 NZ_CP089439:94110-94403 [Citrobacter portucalensis]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW

Download         Length: 294 bp

>AT228252 NZ_CP123597:c2577728-2577426 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTGGGGATCA
GGCAGCCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S1XXW1

Antitoxin

Source ID Structure
AlphaFold DB A0A6M3PBR7

References