Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4795338..4795926 Replicon chromosome
Accession NZ_CP089437
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name PumA Uniprot ID A0A5B0T4T9
Locus tag LT980_RS23260 Protein ID WP_032942059.1
Coordinates 4795338..4795655 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A5B0STC7
Locus tag LT980_RS23265 Protein ID WP_032942057.1
Coordinates 4795648..4795926 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS23240 (LT980_23230) 4791107..4791931 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
LT980_RS23245 (LT980_23235) 4792000..4793223 + 1224 WP_250671514.1 L-sorbose 1-phosphate reductase -
LT980_RS23250 (LT980_23240) 4793225..4794037 + 813 WP_079935013.1 shikimate 5-dehydrogenase -
LT980_RS23255 (LT980_23245) 4794523..4795074 + 552 WP_008786891.1 AAA family ATPase -
LT980_RS23260 (LT980_23250) 4795338..4795655 + 318 WP_032942059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT980_RS23265 (LT980_23255) 4795648..4795926 + 279 WP_032942057.1 putative addiction module antidote protein Antitoxin
LT980_RS23270 (LT980_23260) 4796037..4796726 + 690 WP_032942056.1 dipeptidase PepE -
LT980_RS23275 (LT980_23265) 4796842..4798473 - 1632 WP_048236377.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11993.00 Da        Isoelectric Point: 9.6790

>T228248 WP_032942059.1 NZ_CP089437:4795338-4795655 [Citrobacter portucalensis]
IMEILQTMVFRRWEQNLRDRRAKTLIATRLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQQGCRIIILLCGGDKS
SQANDITLAKMLARTLDSQEIFCHE

Download         Length: 318 bp

>T228248 NZ_CP123597:797543-797851 [Serratia marcescens]
ATGCAGTTTACCGTATATGACAATACATATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGCCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGCTTATGCCCGG
AGATTGAGGTAAACGGCGAAAAGTTTCTCGTTATGACGCATGAGATGGCTGCCGTACGTATTTCACAGCTCGGGAAGGCC
GTTGGTAATGCCAATGAGCACAGGAATCAAATTAAAGCTGCCATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9872.45 Da        Isoelectric Point: 5.8233

>AT228248 WP_032942057.1 NZ_CP089437:4795648-4795926 [Citrobacter portucalensis]
MNKLTHYDPATALVDDEEIAVFMADALETGDAAYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT228248 NZ_CP123597:797304-797540 [Serratia marcescens]
ATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTTCGTGTCAGGGACATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGTGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T4T9

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0STC7

References