Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2564881..2565443 Replicon chromosome
Accession NZ_CP089437
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name higB Uniprot ID A0A1C0NXV4
Locus tag LT980_RS12415 Protein ID WP_003833016.1
Coordinates 2565165..2565443 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6H3AUF8
Locus tag LT980_RS12410 Protein ID WP_003833018.1
Coordinates 2564881..2565165 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS12395 (LT980_12390) 2562576..2563460 + 885 WP_003833024.1 formate dehydrogenase N subunit beta -
LT980_RS12400 (LT980_12395) 2563453..2564109 + 657 WP_003020054.1 formate dehydrogenase-N subunit gamma -
LT980_RS12405 (LT980_12400) 2564239..2564841 + 603 WP_250672200.1 inorganic diphosphatase -
LT980_RS12410 (LT980_12405) 2564881..2565165 - 285 WP_003833018.1 HigA family addiction module antitoxin Antitoxin
LT980_RS12415 (LT980_12410) 2565165..2565443 - 279 WP_003833016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT980_RS12420 (LT980_12415) 2565664..2567379 - 1716 WP_250672201.1 ABC-F family ATP-binding cassette domain-containing protein -
LT980_RS12425 (LT980_12420) 2567689..2569386 - 1698 WP_003833011.1 malate dehydrogenase -
LT980_RS12430 (LT980_12425) 2569566..2569706 - 141 WP_003833009.1 stationary-phase-induced ribosome-associated protein -
LT980_RS12435 (LT980_12430) 2569934..2570365 + 432 WP_195994657.1 OsmC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10667.30 Da        Isoelectric Point: 9.8965

>T228243 WP_003833016.1 NZ_CP089437:c2565443-2565165 [Citrobacter portucalensis]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGERDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T228243 NZ_CP123566:c25802-25521 [Arsenophonus nasoniae]
ATGAGCTATAGTATTGAATTTGAAAAACGCGCATTAAAAGAGTGGAAAAAATTAGCTCATCCAATACGTGAGCAATTTAA
GAAAAAGTTAGTTAAAGTTCTGGAATATCCACATATAAAATCTGCACAATTACACGGACATCAATATCGGTACAAAATCA
AACTAAAATCATCTGGATATCGATTAGTTTATGAAGTAAACGATAATAAACTTTTATTGCTCGTTATTGCCGTGGGAATA
AGAGCTAATAACGAAGTGTATCAGCTAGCAAGCAAACGTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.10 Da        Isoelectric Point: 8.8094

>AT228243 WP_003833018.1 NZ_CP089437:c2565165-2564881 [Citrobacter portucalensis]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAEAQ
KSVDISRLRKLAVQ

Download         Length: 285 bp

>AT228243 NZ_CP123566:c26043-25792 [Arsenophonus nasoniae]
ATGACTTATGAAATATTAACGAGTACGGTTGCAAGCATTACCGATTTAAAACGCAATCCAATGGGTACAGTCGCTGAAGC
AGAAGGAAATGCAGTTGCCATCCTTAACCGAAATGAACCAGCTTTTTACTGCGTACCACCTGATTTATATGCTTATTTTC
AAGAATTGGCAGAAGATACCGAGCTTAATCGTATTGCTGATGAACGCATGAAAAACCCTGAGTTTGTGAGTGTCAATATT
GATGAGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0NXV4

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AUF8

References