Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 341606..342272 Replicon chromosome
Accession NZ_CP089437
Organism Citrobacter portucalensis strain GD21SC92T

Toxin (Protein)


Gene name higB Uniprot ID A0A5B0T6K1
Locus tag LT980_RS01565 Protein ID WP_047408175.1
Coordinates 341955..342272 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5B0T6F5
Locus tag LT980_RS01560 Protein ID WP_048236945.1
Coordinates 341606..341902 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT980_RS01540 (LT980_01540) 338051..338524 - 474 WP_003023524.1 transcription elongation factor GreB -
LT980_RS01545 (LT980_01545) 338750..339469 + 720 WP_001157751.1 two-component system response regulator OmpR -
LT980_RS01550 (LT980_01550) 339466..340818 + 1353 WP_003827658.1 two-component system sensor histidine kinase EnvZ -
LT980_RS01555 (LT980_01555) 340929..341264 + 336 WP_250671637.1 hypothetical protein -
LT980_RS01560 (LT980_01560) 341606..341902 - 297 WP_048236945.1 NadS family protein Antitoxin
LT980_RS01565 (LT980_01565) 341955..342272 - 318 WP_047408175.1 toxin HigB-2 Toxin
LT980_RS01570 (LT980_01570) 342395..344017 - 1623 WP_003023529.1 phosphoenolpyruvate carboxykinase (ATP) -
LT980_RS01575 (LT980_01575) 344396..346114 + 1719 WP_250671638.1 DUF4153 domain-containing protein -
LT980_RS01580 (LT980_01580) 346224..347102 - 879 WP_250671639.1 Hsp33 family molecular chaperone HslO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12255.17 Da        Isoelectric Point: 10.0909

>T228232 WP_047408175.1 NZ_CP089437:c342272-341955 [Citrobacter portucalensis]
MFTFIELQGFSKRRPLLLPDDEFRAFQETLIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

>T228232 NZ_CP123547:c40776-40372 [Arsenophonus nasoniae]
TTGATTAAATATTTACTCGATACAAATATCGTTATATTTACGATTAAACGGAAACCAGTATCGCTATTGCCTAAATTCAA
TCAACATACTAATCAACTGGCTATATCTGCGATAACGTTTGCAGAGCTAATTTTTGGTGCTGAAAAAAGCATGAACTCTG
CTAAAAATTTAGCAACAGTTAATGACTTTGTTTCTCGATTAACCGTTTTACCTTATGACGAACAAGCTGCATTTCATTAC
GGTGATATAAAGGCTAATTTTGAAAAAAAAGAAAAACCAATTGGTGACAATGACTTACATATAGCCGCTCATGCCAGAAG
CAAAGGGCTTGTTGTAGTAACAAACAACACTAGAGAGTTTGAAAGAGTTGAGGGGTTAAGAATCGAAGACTGGACACAAT
TATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11185.95 Da        Isoelectric Point: 7.2052

>AT228232 WP_048236945.1 NZ_CP089437:c341902-341606 [Citrobacter portucalensis]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQRNPFIINQLKAI

Download         Length: 297 bp

>AT228232 NZ_CP123547:c41008-40769 [Arsenophonus nasoniae]
ATGATACAGCAAGGTAAAGTTTTTATGAGCAATCGAACTCAAAATGTTCGACTGCCAGCAGACACACGTTTTCCTGATGA
TGTTAAAGACGTTATTGTTCGAGTGAAGGGTAAAGAACGCATCATTTCTCCTGTACAAAACGCATGGGATAGTTTTTTCT
TATCAGAGCAGTCTGTAACGGATGATTTTTTATCAAACAGAACTGAACAGATAACAAGCGAAAGAGAATCCTTTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B0T6K1

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0T6F5

References