Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4985659..4986175 Replicon chromosome
Accession NZ_CP089385
Organism Klebsiella variicola subsp. variicola strain KPN692

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LUX40_RS23930 Protein ID WP_022065401.1
Coordinates 4985659..4985943 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LUX40_RS23935 Protein ID WP_002886901.1
Coordinates 4985933..4986175 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX40_RS23915 (LUX40_23915) 4980760..4982415 + 1656 WP_042946993.1 alpha,alpha-phosphotrehalase -
LUX40_RS23920 (LUX40_23920) 4982801..4984939 + 2139 WP_044614392.1 anaerobic ribonucleoside-triphosphate reductase -
LUX40_RS23925 (LUX40_23925) 4985191..4985655 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUX40_RS23930 (LUX40_23930) 4985659..4985943 - 285 WP_022065401.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUX40_RS23935 (LUX40_23935) 4985933..4986175 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LUX40_RS23940 (LUX40_23940) 4986253..4988163 - 1911 WP_032756354.1 PRD domain-containing protein -
LUX40_RS23945 (LUX40_23945) 4988186..4989340 - 1155 WP_022065399.1 lactonase family protein -
LUX40_RS23950 (LUX40_23950) 4989466..4990206 - 741 WP_022065398.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11128.97 Da        Isoelectric Point: 10.2849

>T228147 WP_022065401.1 NZ_CP089385:c4985943-4985659 [Klebsiella variicola subsp. variicola]
MTYELEFDPRAWREWQMPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T228147 NZ_CP123365:c1887079-1886976 [Shigella flexneri]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT228147 WP_002886901.1 NZ_CP089385:c4986175-4985933 [Klebsiella variicola subsp. variicola]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT228147 NZ_CP123365:1886975-1887209 [Shigella flexneri]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGCTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References