228124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4487479..4488289 Replicon chromosome
Accession NZ_CP089383
Organism Klebsiella pneumoniae strain KPN342

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag LUX38_RS21915 Protein ID WP_004178461.1
Coordinates 4487479..4488012 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag LUX38_RS21920 Protein ID WP_002887278.1
Coordinates 4488023..4488289 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX38_RS21910 (4486310) 4486310..4487431 + 1122 WP_004186850.1 cupin domain-containing protein -
LUX38_RS21915 (4487479) 4487479..4488012 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
LUX38_RS21920 (4488023) 4488023..4488289 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
LUX38_RS21925 (4488392) 4488392..4489825 - 1434 WP_232410737.1 Cu(+)/Ag(+) sensor histidine kinase -
LUX38_RS21930 (4489815) 4489815..4490498 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
LUX38_RS21935 (4490670) 4490670..4492055 + 1386 WP_232410738.1 efflux transporter outer membrane subunit -
LUX38_RS21940 (4492073) 4492073..4492405 + 333 WP_048337341.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T228124 WP_004178461.1 NZ_CP089383:c4488012-4487479 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T228124 NZ_CP123298:249184-250044 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT228124 WP_002887278.1 NZ_CP089383:c4488289-4488023 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT228124 NZ_CP123298:248577-249191 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLZ1

References