Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4400569..4401191 Replicon chromosome
Accession NZ_CP089282
Organism Pseudomonas amygdali pv. loropetali strain AAC

Toxin (Protein)


Gene name hicA Uniprot ID A0A658PBH1
Locus tag LT107_RS19840 Protein ID WP_003434313.1
Coordinates 4401009..4401191 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A193SSY5
Locus tag LT107_RS19835 Protein ID WP_024661723.1
Coordinates 4400569..4400973 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT107_RS19820 (LT107_19820) 4396335..4397003 + 669 WP_054071059.1 ABC transporter ATP-binding protein -
LT107_RS19825 (LT107_19825) 4397003..4399483 + 2481 WP_243787040.1 FtsX-like permease family protein -
LT107_RS19830 (LT107_19830) 4399473..4400552 + 1080 WP_054071061.1 lipocalin-like domain-containing protein -
LT107_RS19835 (LT107_19835) 4400569..4400973 - 405 WP_024661723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LT107_RS19840 (LT107_19840) 4401009..4401191 - 183 WP_003434313.1 type II toxin-antitoxin system HicA family toxin Toxin
LT107_RS19845 (LT107_19845) 4401475..4403247 + 1773 WP_054071105.1 N-acetylglutaminylglutamine amidotransferase -
LT107_RS19850 (LT107_19850) 4403251..4404999 + 1749 WP_054071106.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6777.99 Da        Isoelectric Point: 10.6643

>T227978 WP_003434313.1 NZ_CP089282:c4401191-4401009 [Pseudomonas amygdali pv. loropetali]
VQSRQLIKELEADGWILDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T227978 NZ_CP123244:949217-949624 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.43 Da        Isoelectric Point: 5.1643

>AT227978 WP_024661723.1 NZ_CP089282:c4400973-4400569 [Pseudomonas amygdali pv. loropetali]
MKYPMCIEWGSETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAAGGGTIPKAGTVAEHARNADFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIKQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT227978 NZ_CP123244:948970-949236 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658PBH1

Antitoxin

Source ID Structure
AlphaFold DB A0A193SSY5

References