Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 152652..153157 Replicon chromosome
Accession NZ_CP089238
Organism Pseudomonas aeruginosa strain JNQH-PA033

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LSG45_RS00730 Protein ID WP_003083773.1
Coordinates 152652..152933 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag LSG45_RS00735 Protein ID WP_003083775.1
Coordinates 152930..153157 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSG45_RS00705 (LSG45_00705) 147903..149252 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
LSG45_RS00710 (LSG45_00710) 149301..149987 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
LSG45_RS00715 (LSG45_00715) 150088..150822 + 735 WP_058152033.1 GntR family transcriptional regulator -
LSG45_RS00720 (LSG45_00720) 151002..151412 + 411 WP_003110659.1 aegerolysin family protein -
LSG45_RS00725 (LSG45_00725) 151444..152352 - 909 WP_023436116.1 LysR family transcriptional regulator -
LSG45_RS00730 (LSG45_00730) 152652..152933 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LSG45_RS00735 (LSG45_00735) 152930..153157 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
LSG45_RS00740 (LSG45_00740) 153333..153953 - 621 WP_234575316.1 hypothetical protein -
LSG45_RS00745 (LSG45_00745) 154054..154581 + 528 WP_234575317.1 LEA type 2 family protein -
LSG45_RS00750 (LSG45_00750) 154654..154995 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LSG45_RS00755 (LSG45_00755) 155080..156507 - 1428 WP_023092260.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T227904 WP_003083773.1 NZ_CP089238:c152933-152652 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T227904 NZ_CP123231:1898427-1898678 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT227904 WP_003083775.1 NZ_CP089238:c153157-152930 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT227904 NZ_CP123231:1898675-1898929 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References