Detailed information of TA system TA022770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1651203..1651761
• Replicon: chromosome
• Accession: NC_010519
• Organism: Haemophilus somnus 2336

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UUG7
• Locus tag: HSM_RS07435
• Protein ID: WP_012340589.1
• Coordinates: 1651489..1651761 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UUG6
• Locus tag: HSM_RS07430
• Protein ID: WP_012340588.1
• Coordinates: 1651203..1651496 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSM_RS07405	1647368..1647871	+	504	WP_012340583.1	thermonuclease family protein	-
HSM_RS07410	1647861..1649060	+	1200	WP_012340584.1	cysteine desulfurase	-
HSM_RS07415	1649057..1649434	+	378	WP_012340585.1	SufE family protein	-
HSM_RS10850	1649749..1649892	+	144	WP_157857767.1	hypothetical protein	-
HSM_RS07420	1650118..1650309	+	192	WP_041605106.1	antitoxin VbhA family protein	-
HSM_RS07425	1650278..1650916	+	639	WP_052292874.1	Fic family protein	-
HSM_RS07430	1651203..1651496	+	294	WP_012340588.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HSM_RS07435	1651489..1651761	+	273	WP_012340589.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HSM_RS07440	1651846..1652988	-	1143	WP_012340590.1	porin	-
HSM_RS07445	1653426..1653707	+	282	WP_012340591.1	virulence factor	-
HSM_RS07450	1653906..1654205	+	300	WP_012340592.1	DUF1778 domain-containing protein	-
HSM_RS07455	1654195..1654701	+	507	WP_012340594.1	GNAT family N-acetyltransferase	-
HSM_RS07460	1654725..1655921	-	1197	WP_012340595.1	lipopolysaccharide assembly protein LapB	-
HSM_RS07465	1655931..1656215	-	285	WP_012340596.1	DUF1049 domain-containing protein	-
HSM_RS07470	1656335..1656619	-	285	WP_011609129.1	integration host factor subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10472.11 Da
• Isoelectric Point: 6.9669

>T22770 WP_012340589.1 NC_010519:1651489-1651761 [Histophilus somni 2336]
MAKRKFDMAKSFKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVDDVVELH
YLDSHSEIFG

Nucleotide

• Length: 273 bp

>T22770 NC_010519:1651489-1651761 [Histophilus somni 2336]
ATGGCTAAACGCAAATTTGATATGGCAAAATCTTTTAAACGTGATTTGAGAAAACATTACTTGGCTTTAGTCGGCGAAGC
ATGGGCAGAGATTTCAAACTGTCTTTTGAATGACTTGCCAATTCCTGAAAAGTATCAAGATCACCCGCTTAAAGGCGATA
AATCAGGCTTTCGAGACTGCCATGTCAAACCGGATTTAGTGTTGATATACAAAATCGTTGATGATGTTGTGGAGTTACAT
TACCTTGATAGCCATAGCGAAATTTTTGGCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11279.60 Da
• Isoelectric Point: 4.7815

>AT22770 WP_012340588.1 NC_010519:1651203-1651496 [Histophilus somni 2336]
MDYTNFNMRLDNDLRGRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FYSLDELNQAIKEISHG

Nucleotide

• Length: 294 bp

>AT22770 NC_010519:1651203-1651496 [Histophilus somni 2336]
ATGGATTATACAAATTTTAATATGCGACTTGATAACGACTTGCGTGGACGGGCTTATCCTATTTTGGAGCAGTATGGATT
GACGCCAAGTCAAGCGGTAAGAATGTTTTTTAATCAGATTGCACAAACCGGTAAAATACCCTTGTCGTTTGATTGGGCGG
AAAATCAAACTTTAACCCCAAAAGCAGCCGCACGGTTACGCCAAACTGAGCAGGAATTCGCCAATGGCGAATTTGAACGC
TTTTATAGCCTAGATGAACTCAATCAAGCGATAAAGGAGATCTCGCATGGCTAA

Structures

Toxin

• AlphaFold DB: B0UUG7

Antitoxin

• AlphaFold DB: B0UUG6