Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3034088..3034923 Replicon chromosome
Accession NZ_CP089142
Organism Escherichia coli strain XD35

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag K0768_RS18170 Protein ID WP_000854821.1
Coordinates 3034088..3034465 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag K0768_RS18175 Protein ID WP_059239988.1
Coordinates 3034555..3034923 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0768_RS18140 (3030769) 3030769..3031473 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
K0768_RS18145 (3031758) 3031758..3031976 + 219 WP_001040187.1 translation initiation factor IF-1 -
K0768_RS18155 (3032467) 3032467..3033309 - 843 WP_063084795.1 DUF4942 domain-containing protein -
K0768_RS18160 (3033394) 3033394..3033591 - 198 WP_000839248.1 DUF957 domain-containing protein -
K0768_RS18165 (3033603) 3033603..3034091 - 489 WP_059239990.1 DUF5983 family protein -
K0768_RS18170 (3034088) 3034088..3034465 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
K0768_RS18175 (3034555) 3034555..3034923 - 369 WP_059239988.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K0768_RS18180 (3034973) 3034973..3035617 - 645 WP_063084794.1 hypothetical protein -
K0768_RS18185 (3035636) 3035636..3035857 - 222 WP_000692353.1 DUF987 domain-containing protein -
K0768_RS18190 (3035926) 3035926..3036402 - 477 WP_001384029.1 RadC family protein -
K0768_RS18195 (3036417) 3036417..3036902 - 486 WP_000214317.1 antirestriction protein -
K0768_RS18200 (3036993) 3036993..3037811 - 819 WP_072651389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T227687 WP_000854821.1 NZ_CP089142:c3034465-3034088 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T227687 NZ_CP123014:c68181-68047 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13565.30 Da        Isoelectric Point: 6.2044

>AT227687 WP_059239988.1 NZ_CP089142:c3034923-3034555 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADALGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT227687 NZ_CP123014:68226-68286 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References