Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1865702..1866533 Replicon chromosome
Accession NZ_CP089142
Organism Escherichia coli strain XD35

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag K0768_RS12315 Protein ID WP_000854814.1
Coordinates 1865702..1866076 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag K0768_RS12320 Protein ID WP_001285585.1
Coordinates 1866165..1866533 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0768_RS12275 (1861097) 1861097..1862263 + 1167 WP_001375226.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
K0768_RS12280 (1862382) 1862382..1862855 + 474 WP_001105414.1 DNA gyrase inhibitor SbmC -
K0768_RS12285 (1863054) 1863054..1864112 + 1059 WP_001200891.1 FUSC family protein -
K0768_RS12290 (1864284) 1864284..1864613 + 330 WP_000450409.1 DUF496 family protein -
K0768_RS12295 (1864714) 1864714..1864848 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
K0768_RS12300 (1864968) 1864968..1865096 + 129 Protein_1758 transposase domain-containing protein -
K0768_RS12305 (1865385) 1865385..1865465 - 81 Protein_1759 hypothetical protein -
K0768_RS12310 (1865511) 1865511..1865705 - 195 WP_000988600.1 DUF5983 family protein -
K0768_RS12315 (1865702) 1865702..1866076 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
K0768_RS12320 (1866165) 1866165..1866533 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
K0768_RS12325 (1866607) 1866607..1866828 - 222 WP_000692323.1 DUF987 domain-containing protein -
K0768_RS12330 (1866891) 1866891..1867367 - 477 WP_001186726.1 RadC family protein -
K0768_RS12335 (1867383) 1867383..1867862 - 480 WP_000860076.1 antirestriction protein -
K0768_RS12340 (1867944) 1867944..1868762 - 819 WP_153449108.1 DUF932 domain-containing protein -
K0768_RS12345 (1868982) 1868982..1869392 - 411 WP_000846713.1 hypothetical protein -
K0768_RS12350 (1869408) 1869408..1869518 - 111 Protein_1768 DNA polymerase III subunit gamma/tau -
K0768_RS12355 (1869604) 1869604..1870350 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T227677 WP_000854814.1 NZ_CP089142:c1866076-1865702 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T227677 NZ_CP123013:1838978-1839232 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT227677 WP_001285585.1 NZ_CP089142:c1866533-1866165 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT227677 NZ_CP123013:1838730-1838981 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References