Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 3357962..3359470 Replicon chromosome
Accession NZ_CP089068
Organism Pseudomonas aeruginosa strain UNC_PaerCF13

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag LSP21_RS15520 Protein ID WP_003119682.1
Coordinates 3357962..3358549 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag LSP21_RS15525 Protein ID WP_003091607.1
Coordinates 3358616..3359470 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP21_RS15515 (LSP21_15520) 3354217..3357696 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LSP21_RS15520 (LSP21_15525) 3357962..3358549 + 588 WP_003119682.1 GNAT family protein Toxin
LSP21_RS15525 (LSP21_15530) 3358616..3359470 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
LSP21_RS15530 (LSP21_15535) 3359567..3361732 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
LSP21_RS15535 (LSP21_15540) 3361907..3363781 + 1875 WP_010793244.1 MFS transporter -
LSP21_RS15540 (LSP21_15545) 3363842..3364051 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T227614 WP_003119682.1 NZ_CP089068:3357962-3358549 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T227614 NZ_CP123005:c556835-556416 [Sinorhizobium meliloti]
GTGAGCAGGCTGTACATGCTGGACACCAATATCGTGTCCGAGCTTGCGCGAAACCCACAGGGGGCTGTCACTAAACGCAT
TGCCGAGGTAGGACCGGAGGCAGTCTGCGTCAGCATCATTACGGCGGCAGAGTTACGCTATGGATGCGCCAAGAAGGGAT
CACCGAAGCTACTGGCGCAAATCGAGGCCATTCTTGGAAGTATGCAAGTGCTTGCGCTCGATGTGCCTGCTGATGCCGAA
TATGGCAACATCCGGGCTGAACTGGAGACCGCTGGTAAGCCCATCGGTCCGAATGACCTGTTCATCGCCGCTCATGCCTG
TGTGCTTGGAGCGGTGCTGGTAACGGTCAACAGTAGCGAGTTCACACGCGTTCGTGATCTCAAGGTCGAGAACTGGCTGG
ATTTCACTTCTTCGGGTTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT227614 WP_003091607.1 NZ_CP089068:3358616-3359470 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT227614 NZ_CP123005:c557101-556832 [Sinorhizobium meliloti]
ATGCCCCAACTCCGACACGACGAACCACCACCGCCAAGGGAAGCCAAGCTCTTCCGAAATAATAGAAGTCAGGCTGTACG
TATCCCCGCTGATTTTGAGCTTCCCGGCGATCGGGTGATGATCCATCGGGATGGAGATCGGCTGATAATCGAGCCGGTGC
TCCGCAAGAACTTGCTGGAAGTACTGGCAGGTTTGGAGCCGCTCGGGTCTGAAGATGAGTTCCCTGACGTTGATGAAACC
CTGCTGCCGGGGAAGGATGTCGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References