Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799617..800274 Replicon chromosome
Accession NZ_CP088988
Organism Klebsiella pneumoniae strain 53322

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LRZ75_RS03940 Protein ID WP_002916310.1
Coordinates 799864..800274 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LRZ75_RS03935 Protein ID WP_002916312.1
Coordinates 799617..799883 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ75_RS03910 (794825) 794825..796258 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LRZ75_RS03915 (796377) 796377..797105 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LRZ75_RS03920 (797155) 797155..797466 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LRZ75_RS03925 (797630) 797630..798289 + 660 WP_002916317.1 hemolysin III family protein -
LRZ75_RS03930 (798388) 798388..799371 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LRZ75_RS03935 (799617) 799617..799883 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LRZ75_RS03940 (799864) 799864..800274 + 411 WP_002916310.1 protein YgfX Toxin
LRZ75_RS03945 (800281) 800281..800802 - 522 WP_002916308.1 flavodoxin FldB -
LRZ75_RS03950 (800903) 800903..801799 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LRZ75_RS03955 (801822) 801822..802535 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LRZ75_RS03960 (802541) 802541..804274 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227242 WP_002916310.1 NZ_CP088988:799864-800274 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227242 NZ_CP122809:70382-70684 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227242 WP_002916312.1 NZ_CP088988:799617-799883 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227242 NZ_CP122809:70755-71093 [Escherichia coli]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References