Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4930898..4931414 Replicon chromosome
Accession NZ_CP088982
Organism Klebsiella pneumoniae strain 53357

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LRZ78_RS23685 Protein ID WP_004178374.1
Coordinates 4930898..4931182 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LRZ78_RS23690 Protein ID WP_002886901.1
Coordinates 4931172..4931414 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ78_RS23660 (4926294) 4926294..4926557 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LRZ78_RS23665 (4926687) 4926687..4926860 + 174 WP_041169004.1 hypothetical protein -
LRZ78_RS23670 (4926863) 4926863..4927606 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LRZ78_RS23675 (4927963) 4927963..4930101 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LRZ78_RS23680 (4930430) 4930430..4930894 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRZ78_RS23685 (4930898) 4930898..4931182 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRZ78_RS23690 (4931172) 4931172..4931414 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRZ78_RS23695 (4931492) 4931492..4933402 - 1911 WP_012737231.1 PRD domain-containing protein -
LRZ78_RS23700 (4933425) 4933425..4934579 - 1155 WP_012737230.1 lactonase family protein -
LRZ78_RS23705 (4934646) 4934646..4935386 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T227210 WP_004178374.1 NZ_CP088982:c4931182-4930898 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T227210 NZ_CP122768:c4959083-4958733 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGTCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT227210 WP_002886901.1 NZ_CP088982:c4931414-4931172 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT227210 NZ_CP122768:c4959328-4959077 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAATAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References