Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805806..806463 Replicon chromosome
Accession NZ_CP088978
Organism Klebsiella pneumoniae strain KP015

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LST75_RS03985 Protein ID WP_002916310.1
Coordinates 806053..806463 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LST75_RS03980 Protein ID WP_002916312.1
Coordinates 805806..806072 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LST75_RS03955 (LST75_03955) 800962..802395 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LST75_RS03960 (LST75_03960) 802514..803242 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LST75_RS03965 (LST75_03965) 803292..803603 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LST75_RS03970 (LST75_03970) 803767..804426 + 660 WP_002916317.1 hemolysin III family protein -
LST75_RS03975 (LST75_03975) 804577..805560 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LST75_RS03980 (LST75_03980) 805806..806072 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LST75_RS03985 (LST75_03985) 806053..806463 + 411 WP_002916310.1 protein YgfX Toxin
LST75_RS03990 (LST75_03990) 806470..806991 - 522 WP_002916308.1 flavodoxin FldB -
LST75_RS03995 (LST75_03995) 807092..807988 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LST75_RS04000 (LST75_04000) 808011..808724 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LST75_RS04005 (LST75_04005) 808730..810463 + 1734 WP_023328361.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T227177 WP_002916310.1 NZ_CP088978:806053-806463 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T227177 NZ_CP122758:3537114-3537332 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT227177 WP_002916312.1 NZ_CP088978:805806-806072 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT227177 NZ_CP122758:3536714-3537088 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References