Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3543415..3544014 | Replicon | chromosome |
| Accession | NZ_CP088919 | ||
| Organism | Rhodanobacter denitrificans strain DSM-24678 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | I4WT83 |
| Locus tag | LRK24_RS16300 | Protein ID | WP_007510748.1 |
| Coordinates | 3543733..3544014 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRK24_RS16295 | Protein ID | WP_007510746.1 |
| Coordinates | 3543415..3543720 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRK24_RS16275 (LRK24_16275) | 3538983..3539213 | - | 231 | WP_007510737.1 | glutaredoxin family protein | - |
| LRK24_RS16280 (LRK24_16280) | 3539289..3540671 | + | 1383 | WP_007510739.1 | L-serine ammonia-lyase | - |
| LRK24_RS16285 (LRK24_16285) | 3540795..3541241 | - | 447 | WP_007510742.1 | hypothetical protein | - |
| LRK24_RS16290 (LRK24_16290) | 3541334..3543277 | + | 1944 | WP_043292508.1 | DNA methyltransferase | - |
| LRK24_RS16295 (LRK24_16295) | 3543415..3543720 | - | 306 | WP_007510746.1 | HigA family addiction module antitoxin | Antitoxin |
| LRK24_RS16300 (LRK24_16300) | 3543733..3544014 | - | 282 | WP_007510748.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LRK24_RS16305 (LRK24_16305) | 3544100..3547039 | + | 2940 | WP_007510750.1 | DEAD/DEAH box helicase family protein | - |
| LRK24_RS16310 (LRK24_16310) | 3547316..3548980 | + | 1665 | WP_007510753.1 | APC family permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10873.31 Da Isoelectric Point: 7.8618
>T227130 WP_007510748.1 NZ_CP088919:c3544014-3543733 [Rhodanobacter denitrificans]
VIRSFADKETARLSATGTSRRFPPDIVRWALSRLKYLHLATCPEDLREPFSNRLEMLSGNRAGQWSIRINDQWRLCFRFE
GGDAFDVEIVDYH
VIRSFADKETARLSATGTSRRFPPDIVRWALSRLKYLHLATCPEDLREPFSNRLEMLSGNRAGQWSIRINDQWRLCFRFE
GGDAFDVEIVDYH
Download Length: 282 bp
>T227130 NZ_CP122722:c2340982-2340788 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCTGTTACGGTGAAAGCAATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11196.00 Da Isoelectric Point: 7.3200
>AT227130 WP_007510746.1 NZ_CP088919:c3543720-3543415 [Rhodanobacter denitrificans]
MSIPATTNGLPPIHPGELLEEILSDHGMSQAAFARAIGVSPMRISHVIREERPVTAELALRFGRAFGQSPQFWMNMQTDY
DLKIAERELKASLRKVLPLAA
MSIPATTNGLPPIHPGELLEEILSDHGMSQAAFARAIGVSPMRISHVIREERPVTAELALRFGRAFGQSPQFWMNMQTDY
DLKIAERELKASLRKVLPLAA
Download Length: 306 bp
>AT227130 NZ_CP122722:2340611-2340789 [Escherichia coli]
GACGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCAGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTAGCGGTAATTTT
GACGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCAGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTAGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|