Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HTH_37(antitoxin)
Location 3021172..3021800 Replicon chromosome
Accession NZ_CP088919
Organism Rhodanobacter denitrificans strain DSM-24678

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LRK24_RS13875 Protein ID WP_007513282.1
Coordinates 3021624..3021800 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LRK24_RS13870 Protein ID WP_007513280.1
Coordinates 3021172..3021591 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK24_RS13855 (LRK24_13855) 3018413..3019042 + 630 WP_236100272.1 nuclease-related domain-containing protein -
LRK24_RS13860 (LRK24_13860) 3018944..3020116 - 1173 WP_007514505.1 IS4 family transposase -
LRK24_RS13865 (LRK24_13865) 3020282..3020791 + 510 WP_157781477.1 hypothetical protein -
LRK24_RS13870 (LRK24_13870) 3021172..3021591 - 420 WP_007513280.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LRK24_RS13875 (LRK24_13875) 3021624..3021800 - 177 WP_007513282.1 type II toxin-antitoxin system HicA family toxin Toxin
LRK24_RS13880 (LRK24_13880) 3021979..3022641 + 663 WP_007513284.1 DUF502 domain-containing protein -
LRK24_RS13885 (LRK24_13885) 3022726..3024537 + 1812 WP_007513286.1 M14 family metallopeptidase -
LRK24_RS13890 (LRK24_13890) 3024658..3026781 + 2124 WP_007513288.1 M13-type metalloendopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6834.93 Da        Isoelectric Point: 11.0888

>T227129 WP_007513282.1 NZ_CP088919:c3021800-3021624 [Rhodanobacter denitrificans]
MKYSEFQRWLRQQGVSFEPGKGSHQLARYRGRTSVFPFHGSKEMPEPLRKKILKDLGL

Download         Length: 177 bp

>T227129 NZ_CP122722:c2188918-2188811 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15470.93 Da        Isoelectric Point: 8.0203

>AT227129 WP_007513280.1 NZ_CP088919:c3021591-3021172 [Rhodanobacter denitrificans]
MKYPVKLTRADSVVMVTCPDLPEFSSVGDTEGEALREAVDGIETTLQAYMQDRRDIPPPGARKRGQRLVELPPLAVAKLG
LYRAMREQGLRKADLARRLDVHLPQVDRLLDLRHSSKLEQVEAALNALGYRIELAVLAA

Download         Length: 420 bp

>AT227129 NZ_CP122722:2188965-2189031 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References