Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2868311..2868918 Replicon chromosome
Accession NZ_CP088919
Organism Rhodanobacter denitrificans strain DSM-24678

Toxin (Protein)


Gene name higB Uniprot ID I4WTS9
Locus tag LRK24_RS13150 Protein ID WP_007510671.1
Coordinates 2868604..2868918 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LRK24_RS13145 Protein ID WP_015447258.1
Coordinates 2868311..2868589 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK24_RS13120 (LRK24_13120) 2865063..2865404 - 342 WP_007512800.1 lipid-A-disaccharide synthase N-terminal domain-containing protein -
LRK24_RS13130 (LRK24_13130) 2865699..2865962 - 264 WP_007512798.1 hypothetical protein -
LRK24_RS13135 (LRK24_13135) 2866080..2867261 + 1182 Protein_2584 IS256 family transposase -
LRK24_RS13140 (LRK24_13140) 2867279..2868241 + 963 WP_236100265.1 IS701 family transposase -
LRK24_RS13145 (LRK24_13145) 2868311..2868589 - 279 WP_015447258.1 helix-turn-helix domain-containing protein Antitoxin
LRK24_RS13150 (LRK24_13150) 2868604..2868918 - 315 WP_007510671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRK24_RS13155 (LRK24_13155) 2869390..2873121 - 3732 WP_007510668.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2866080..2867369 1289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11641.42 Da        Isoelectric Point: 9.8349

>T227128 WP_007510671.1 NZ_CP088919:c2868918-2868604 [Rhodanobacter denitrificans]
MIFVETPIFTAQIKDLLSDDDYGAFQRYLAENPEAGDVIKETGGLRKIRVAAKGHGKSGGARVIYYYFVSASRIAMVFAY
PKNVQENLTPAQKAALKKVIEQWR

Download         Length: 315 bp

>T227128 NZ_CP122722:c2188382-2188275 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10263.75 Da        Isoelectric Point: 7.2060

>AT227128 WP_015447258.1 NZ_CP088919:c2868589-2868311 [Rhodanobacter denitrificans]
MFDNLMESVTQMDEIVRGERQPSREVHIDALAVKEIRRATGLSQAKFAGIVDVQVGTLRNWEQGRREPTGPAKALLRAIS
KDPKHVLEALAD

Download         Length: 279 bp

>AT227128 NZ_CP122722:2188435-2188496 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A154QK28

Antitoxin

Source ID Structure

References