Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4216342..4216858 Replicon chromosome
Accession NZ_CP088901
Organism Salmonella enterica subsp. enterica serovar Muenchen strain 180135033

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LRP35_RS20710 Protein ID WP_000220578.1
Coordinates 4216342..4216626 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LRP35_RS20715 Protein ID WP_000212724.1
Coordinates 4216616..4216858 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP35_RS20695 (4211458) 4211458..4213110 + 1653 WP_021294549.1 alpha,alpha-phosphotrehalase -
LRP35_RS20700 (4213519) 4213519..4215657 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LRP35_RS20705 (4215874) 4215874..4216338 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LRP35_RS20710 (4216342) 4216342..4216626 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRP35_RS20715 (4216616) 4216616..4216858 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LRP35_RS20720 (4216936) 4216936..4218849 - 1914 WP_001212145.1 BglG family transcription antiterminator -
LRP35_RS20725 (4218866) 4218866..4219606 - 741 WP_000779259.1 KDGP aldolase family protein -
LRP35_RS20730 (4219603) 4219603..4220721 - 1119 WP_023197793.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LRP35_RS20735 (4220705) 4220705..4221838 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T227113 WP_000220578.1 NZ_CP088901:c4216626-4216342 [Salmonella enterica subsp. enterica serovar Muenchen]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T227113 NZ_CP122719:c4579703-4579518 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTCTCTCTTTTAGGAGCTGTAGTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT227113 WP_000212724.1 NZ_CP088901:c4216858-4216616 [Salmonella enterica subsp. enterica serovar Muenchen]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT227113 NZ_CP122719:c4580027-4579731 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References