Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2791158..2791810 Replicon chromosome
Accession NZ_CP088151
Organism Mesorhizobium mediterraneum strain R31

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LRP31_RS13550 Protein ID WP_095488954.1
Coordinates 2791158..2791547 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LRP31_RS13555 Protein ID WP_095488955.1
Coordinates 2791544..2791810 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRP31_RS13525 (LRP31_13495) 2786828..2787253 + 426 WP_095488951.1 VOC family protein -
LRP31_RS13530 (LRP31_13500) 2787367..2788278 + 912 WP_206073027.1 arginase family protein -
LRP31_RS13535 (LRP31_13505) 2788382..2789329 - 948 WP_095488952.1 trypsin-like peptidase domain-containing protein -
LRP31_RS13540 (LRP31_13510) 2789601..2790473 + 873 WP_095488953.1 S1C family serine protease -
LRP31_RS13545 (LRP31_13515) 2790482..2791150 + 669 WP_206073028.1 response regulator transcription factor -
LRP31_RS13550 (LRP31_13520) 2791158..2791547 - 390 WP_095488954.1 type II toxin-antitoxin system VapC family toxin Toxin
LRP31_RS13555 (LRP31_13525) 2791544..2791810 - 267 WP_095488955.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LRP31_RS13560 (LRP31_13530) 2791976..2792842 + 867 WP_095488956.1 NAD(P)-dependent oxidoreductase -
LRP31_RS13565 (LRP31_13535) 2793259..2795463 - 2205 WP_095488957.1 OmpA family protein -
LRP31_RS13570 (LRP31_13540) 2795663..2796109 + 447 WP_095489233.1 YcgN family cysteine cluster protein -
LRP31_RS13575 (LRP31_13545) 2796439..2796807 + 369 WP_095488958.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14216.42 Da        Isoelectric Point: 5.6430

>T226853 WP_095488954.1 NZ_CP088151:c2791547-2791158 [Mesorhizobium mediterraneum]
MIIDSSALVAVLRAEPDHERFVLAIAQAKRRLLAAPTFLETTMVLAGGWQDEILDRLDSFLRVASIETIAFTADHAAVAR
QAFLRYGKGRHPAALNFGDCISYATARLEAMPLLFKGDDFRLTDIEPAV

Download         Length: 390 bp

>T226853 NZ_CP122643:2027725-2027979 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10102.45 Da        Isoelectric Point: 4.9437

>AT226853 WP_095488955.1 NZ_CP088151:c2791810-2791544 [Mesorhizobium mediterraneum]
MALSIKNTEVEQLARELARRRRVSVTEAIRQSLEREVARERLVPRDEADDLFQRLMAISDSAGKIPKRENAMTDDEVLGY
DEFGIPTK

Download         Length: 267 bp

>AT226853 NZ_CP122643:2027477-2027728 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References