Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4378573..4379354 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LRM92_RS21500 Protein ID WP_000626099.1
Coordinates 4378573..4379064 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LRM92_RS21505 Protein ID WP_001110452.1
Coordinates 4379061..4379354 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS21465 (4374568) 4374568..4375143 + 576 WP_001188509.1 transcriptional regulator -
LRM92_RS21475 (4375414) 4375414..4375491 - 78 Protein_4204 helix-turn-helix domain-containing protein -
LRM92_RS21480 (4375582) 4375582..4375914 - 333 WP_001165471.1 MerR family transcriptional regulator -
LRM92_RS21485 (4375986) 4375986..4376363 + 378 WP_000916345.1 EthD family reductase -
LRM92_RS21490 (4377396) 4377396..4377470 + 75 Protein_4207 porin family protein -
LRM92_RS21495 (4377573) 4377573..4378325 + 753 WP_000842434.1 non-specific acid phosphatase -
LRM92_RS21500 (4378573) 4378573..4379064 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LRM92_RS21505 (4379061) 4379061..4379354 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LRM92_RS21510 (4379671) 4379671..4379892 + 222 WP_001576552.1 hypothetical protein -
LRM92_RS21515 (4380157) 4380157..4381032 + 876 WP_000921674.1 AraC family transcriptional regulator -
LRM92_RS21520 (4381029) 4381029..4381316 + 288 WP_001269916.1 transcriptional regulator RtsB -
LRM92_RS21525 (4381339) 4381339..4381554 + 216 WP_001595136.1 hypothetical protein -
LRM92_RS21530 (4381562) 4381562..4381831 + 270 WP_010989096.1 hypothetical protein -
LRM92_RS21535 (4382125) 4382125..4383030 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T226809 WP_000626099.1 NZ_CP088138:c4379064-4378573 [Salmonella enterica subsp. enterica serovar Hissar]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T226809 NZ_CP122629:c4396644-4396294 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT226809 WP_001110452.1 NZ_CP088138:c4379354-4379061 [Salmonella enterica subsp. enterica serovar Hissar]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT226809 NZ_CP122629:c4396889-4396638 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References