Detailed information of TA system TA226637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE(toxin)
• Location: 1209697..1210219
• Replicon: chromosome
• Accession: NZ_CP088113
• Organism: Sinorhizobium meliloti strain RRI128

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: SmelRRI128_RS06005
• Protein ID: WP_027990011.1
• Coordinates: 1209697..1209984 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3M0Q4X5
• Locus tag: SmelRRI128_RS06010
• Protein ID: WP_027990010.1
• Coordinates: 1209974..1210219 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SmelRRI128_RS05985 (SmelRRI128_05985)	1205995..1206312	+	318	WP_027990013.1	DUF2849 domain-containing protein	-
SmelRRI128_RS05990 (SmelRRI128_05990)	1206327..1208000	+	1674	WP_027990012.1	nitrite/sulfite reductase	-
SmelRRI128_RS05995 (SmelRRI128_05995)	1208018..1208518	+	501	WP_010969243.1	DUF934 domain-containing protein	-
SmelRRI128_RS06000 (SmelRRI128_06000)	1208664..1209476	+	813	WP_003537440.1	ferredoxin--NADP reductase	-
SmelRRI128_RS06005 (SmelRRI128_06005)	1209697..1209984	-	288	WP_027990011.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SmelRRI128_RS06010 (SmelRRI128_06010)	1209974..1210219	-	246	WP_027990010.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SmelRRI128_RS06015 (SmelRRI128_06015)	1210409..1211185	-	777	WP_003535037.1	amino acid ABC transporter ATP-binding protein	-
SmelRRI128_RS06020 (SmelRRI128_06020)	1211204..1212358	-	1155	WP_027990009.1	amino acid ABC transporter permease	-
SmelRRI128_RS06025 (SmelRRI128_06025)	1212363..1213556	-	1194	WP_010969246.1	amino acid ABC transporter permease	-
SmelRRI128_RS06030 (SmelRRI128_06030)	1213661..1214686	-	1026	WP_003535031.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-76)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11108.05 Da
• Isoelectric Point: 11.1450

>T226637 WP_027990011.1 NZ_CP088113:c1209984-1209697 [Sinorhizobium meliloti]
MPYSLEFLPSARKEWDKLGATIRQQFVKKLRERLERPRIPSAALHGMPDHYKIKLRQLGYRLVYRVDDGVVTVLAVAVGK
RERGDVYNLMRARGR

Nucleotide

• Length: 288 bp

>T226637 NZ_CP122587:c4979120-4978203 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8887.12 Da
• Isoelectric Point: 4.1473

>AT226637 WP_027990010.1 NZ_CP088113:c1210219-1209974 [Sinorhizobium meliloti]
MQRVEASVAVSVSDLKKSPTAVMGEAQGEPVAVLNHNRVMAYLVPADVYESMLERLDDLYLAELVKERADEKGEPVDIDA
L

Nucleotide

• Length: 246 bp

>AT226637 NZ_CP122587:c4979884-4979126 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A3M0Q4X5