Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796818..797475 Replicon chromosome
Accession NZ_CP087978
Organism Klebsiella variicola subsp. variicola strain ZH07

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LPW14_RS03920 Protein ID WP_002916310.1
Coordinates 797065..797475 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LPW14_RS03915 Protein ID WP_002916312.1
Coordinates 796818..797084 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPW14_RS03890 (LPW14_03890) 791967..793400 - 1434 WP_230648805.1 6-phospho-beta-glucosidase BglA -
LPW14_RS03895 (LPW14_03895) 793520..794248 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
LPW14_RS03900 (LPW14_03900) 794299..794610 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
LPW14_RS03905 (LPW14_03905) 794774..795433 + 660 WP_008806429.1 hemolysin III family protein -
LPW14_RS03910 (LPW14_03910) 795589..796572 - 984 WP_080930388.1 tRNA-modifying protein YgfZ -
LPW14_RS03915 (LPW14_03915) 796818..797084 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LPW14_RS03920 (LPW14_03920) 797065..797475 + 411 WP_002916310.1 protein YgfX Toxin
LPW14_RS03925 (LPW14_03925) 797482..798003 - 522 WP_008806427.1 flavodoxin FldB -
LPW14_RS03930 (LPW14_03930) 798104..799000 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
LPW14_RS03935 (LPW14_03935) 799023..799736 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LPW14_RS03940 (LPW14_03940) 799742..801475 + 1734 WP_117106322.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T226499 WP_002916310.1 NZ_CP087978:797065-797475 [Klebsiella variicola subsp. variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T226499 NZ_CP122503:203371-203478 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT226499 WP_002916312.1 NZ_CP087978:796818-797084 [Klebsiella variicola subsp. variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT226499 NZ_CP122503:c203322-203259 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References