Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1914889..1915538 Replicon chromosome
Accession NZ_CP087865
Organism Moraxella bovis strain SAM57868

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP122_RS09330 Protein ID WP_264677937.1
Coordinates 1914889..1915290 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP122_RS09335 Protein ID WP_112741908.1
Coordinates 1915305..1915538 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP122_RS09300 (LP122_09210) 1910542..1910715 + 174 WP_264677941.1 hypothetical protein -
LP122_RS09305 (LP122_09215) 1910967..1911386 + 420 WP_264677940.1 S4 domain-containing protein -
LP122_RS09315 (LP122_09225) 1912124..1912813 + 690 WP_264677939.1 SIMPL domain-containing protein -
LP122_RS09320 (LP122_09230) 1912913..1913743 - 831 WP_264677938.1 inositol monophosphatase family protein -
LP122_RS09325 (LP122_09235) 1913865..1914365 - 501 WP_112741909.1 WG repeat-containing protein -
LP122_RS09330 (LP122_09240) 1914889..1915290 - 402 WP_264677937.1 type II toxin-antitoxin system VapC family toxin Toxin
LP122_RS09335 (LP122_09245) 1915305..1915538 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP122_RS09340 (LP122_09250) 1915586..1917685 - 2100 WP_264683682.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP122_RS09345 (LP122_09255) 1917906..1918499 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP122_RS09350 (LP122_09260) 1918519..1919511 + 993 WP_264683684.1 oxygen-dependent coproporphyrinogen oxidase -
LP122_RS09355 (LP122_09265) 1919693..1920142 + 450 WP_264683685.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.29 Da        Isoelectric Point: 6.8426

>T226432 WP_264677937.1 NZ_CP087865:c1915290-1914889 [Moraxella bovis]
MFSFMLDTNICIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226432 NZ_CP122492:193573-193680 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226432 WP_112741908.1 NZ_CP087865:c1915538-1915305 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226432 NZ_CP122492:c193516-193459 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References