Detailed information of TA system TA226335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 313803..314409
• Replicon: chromosome
• Accession: NZ_CP087843
• Organism: Moraxella bovis strain SAM58106

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP121_RS01600
• Protein ID: WP_228157738.1
• Coordinates: 313803..314138 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP121_RS01605
• Protein ID: WP_078274722.1
• Coordinates: 314128..314409 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP121_RS01555	308865..308999	+	135	WP_264676041.1	hypothetical protein	-
LP121_RS01560 (LP121_01545)	309051..309206	+	156	WP_158079680.1	hypothetical protein	-
LP121_RS01565 (LP121_01550)	309201..309476	-	276	WP_078274708.1	hypothetical protein	-
LP121_RS01570 (LP121_01555)	309763..310008	-	246	WP_078274709.1	hypothetical protein	-
LP121_RS01575 (LP121_01560)	310131..310508	-	378	WP_264684286.1	hypothetical protein	-
LP121_RS01580 (LP121_01565)	310507..310836	+	330	WP_264684287.1	hypothetical protein	-
LP121_RS01585 (LP121_01570)	311329..311964	+	636	WP_264684288.1	hypothetical protein	-
LP121_RS01590 (LP121_01575)	312200..312493	+	294	WP_078274720.1	DUF2523 family protein	-
LP121_RS01595 (LP121_01580)	312579..313739	+	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP121_RS01600 (LP121_01585)	313803..314138	+	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP121_RS01605 (LP121_01590)	314128..314409	+	282	WP_078274722.1	NadS family protein	Antitoxin
LP121_RS01610 (LP121_01595)	314459..315283	+	825	WP_078274723.1	site-specific integrase	-
LP121_RS01615 (LP121_01600)	315399..315611	+	213	WP_078274724.1	hypothetical protein	-
LP121_RS01620 (LP121_01605)	315651..316373	-	723	WP_029103568.1	nitroreductase family protein	-
LP121_RS01625 (LP121_01610)	316518..317843	-	1326	WP_112741690.1	hemolysin family protein	-
LP121_RS01630 (LP121_01615)	317953..318711	-	759	WP_078274726.1	YciK family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226335 WP_228157738.1 NZ_CP087843:313803-314138 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226335 NZ_CP122448:c3600620-3600318 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226335 WP_078274722.1 NZ_CP087843:314128-314409 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226335 NZ_CP122448:c3600282-3599941 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGTCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG