Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 648782..649431 Replicon chromosome
Accession NZ_CP087805
Organism Moraxella bovis strain SAM57942

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP119_RS03385 Protein ID WP_264677937.1
Coordinates 649030..649431 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP119_RS03380 Protein ID WP_112741908.1
Coordinates 648782..649015 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP119_RS03360 (LP119_03340) 644178..644627 - 450 WP_249097919.1 cytochrome c -
LP119_RS03365 (LP119_03345) 644809..645801 - 993 WP_264697703.1 oxygen-dependent coproporphyrinogen oxidase -
LP119_RS03370 (LP119_03350) 645821..646414 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP119_RS03375 (LP119_03355) 646635..648734 + 2100 WP_264683682.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP119_RS03380 (LP119_03360) 648782..649015 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP119_RS03385 (LP119_03365) 649030..649431 + 402 WP_264677937.1 type II toxin-antitoxin system VapC family toxin Toxin
LP119_RS03390 (LP119_03370) 649955..650455 + 501 WP_112741909.1 WG repeat-containing protein -
LP119_RS03395 (LP119_03375) 650577..651407 + 831 WP_264677938.1 inositol monophosphatase family protein -
LP119_RS03400 (LP119_03380) 651507..652196 - 690 WP_264677939.1 SIMPL domain-containing protein -
LP119_RS03410 (LP119_03390) 652934..653353 - 420 WP_264677940.1 S4 domain-containing protein -
LP119_RS03415 (LP119_03395) 653605..653778 - 174 WP_264677941.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.29 Da        Isoelectric Point: 6.8426

>T226213 WP_264677937.1 NZ_CP087805:649030-649431 [Moraxella bovis]
MFSFMLDTNICIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226213 NZ_CP122318:2810511-2810861 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226213 WP_112741908.1 NZ_CP087805:648782-649015 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226213 NZ_CP122318:2810266-2810517 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References