Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1474751..1475407 Replicon chromosome
Accession NZ_CP087803
Organism Moraxella bovis strain SAM57947

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP097_RS07425 Protein ID WP_264676287.1
Coordinates 1474751..1474933 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP097_RS07430 Protein ID WP_264676286.1
Coordinates 1474994..1475407 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP097_RS07405 (LP097_07315) 1470728..1472124 - 1397 Protein_1440 phage terminase large subunit -
LP097_RS07410 (LP097_07320) 1472124..1472663 - 540 WP_264676291.1 terminase small subunit -
LP097_RS07415 (LP097_07325) 1472776..1472985 + 210 WP_264676290.1 hypothetical protein -
LP097_RS14930 1473045..1473236 + 192 WP_276591270.1 transcriptional regulator -
LP097_RS07420 (LP097_07330) 1473647..1474351 - 705 WP_264676288.1 BRO family protein -
LP097_RS07425 (LP097_07335) 1474751..1474933 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP097_RS07430 (LP097_07340) 1474994..1475407 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP097_RS07435 (LP097_07345) 1475418..1475819 - 402 WP_264676285.1 antiterminator Q family protein -
LP097_RS07440 (LP097_07350) 1475803..1476024 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP097_RS07445 (LP097_07355) 1476021..1476176 - 156 WP_264676283.1 hypothetical protein -
LP097_RS07450 (LP097_07360) 1476313..1476798 - 486 WP_264688965.1 recombination protein NinB -
LP097_RS07455 (LP097_07365) 1476862..1477539 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP097_RS07460 (LP097_07370) 1478201..1478398 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP097_RS07465 (LP097_07375) 1478445..1478723 - 279 WP_264682994.1 hypothetical protein -
LP097_RS07470 (LP097_07380) 1478720..1479127 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP097_RS07475 (LP097_07385) 1479124..1479759 - 636 WP_264688921.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1443278..1495242 51964


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226205 WP_264676287.1 NZ_CP087803:1474751-1474933 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226205 NZ_CP122318:c1405429-1405253 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226205 WP_264676286.1 NZ_CP087803:1474994-1475407 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226205 NZ_CP122318:c1405207-1404791 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References