Detailed information of TA system TA226179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 432804..433362
• Replicon: chromosome
• Accession: NZ_CP087798
• Organism: Moraxella bovis strain SAM57954

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP098_RS02180
• Protein ID: WP_228157760.1
• Coordinates: 433090..433362 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP098_RS02175
• Protein ID: WP_029103533.1
• Coordinates: 432804..433097 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP098_RS02155 (LP098_02140)	428315..429649	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP098_RS02160 (LP098_02145)	429769..430380	+	612	WP_112741794.1	methyltransferase	-
LP098_RS02165 (LP098_02150)	430401..431117	+	717	WP_078275193.1	hypothetical protein	-
LP098_RS02170 (LP098_02155)	431326..432660	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP098_RS02175 (LP098_02160)	432804..433097	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP098_RS02180 (LP098_02165)	433090..433362	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP098_RS02185 (LP098_02170)	433427..433882	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP098_RS02190 (LP098_02175)	433967..434344	+	378	WP_264675984.1	hypothetical protein	-
LP098_RS02195 (LP098_02180)	434702..435961	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP098_RS02200 (LP098_02185)	436041..436304	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP098_RS02205 (LP098_02190)	436301..436693	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP098_RS02210 (LP098_02195)	436816..437346	+	531	WP_078275187.1	HI_0552 family protein	-
LP098_RS02215 (LP098_02200)	437343..437909	-	567	WP_078275186.1	hypothetical protein	-
LP098_RS02220 (LP098_02205)	437912..438148	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226179 WP_228157760.1 NZ_CP087798:433090-433362 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226179 NZ_CP122317:c1441704-1441369 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226179 WP_029103533.1 NZ_CP087798:432804-433097 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226179 NZ_CP122317:c1441952-1441704 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6