Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2328281..2328939 Replicon chromosome
Accession NZ_CP087781
Organism Moraxella bovis strain SAM57978

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP129_RS11815 Protein ID WP_078274940.1
Coordinates 2328751..2328939 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP129_RS11810 Protein ID WP_112741846.1
Coordinates 2328281..2328688 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP129_RS11780 (LP129_11685) 2323512..2325341 - 1830 WP_078274936.1 hypothetical protein -
LP129_RS11785 (LP129_11690) 2325329..2325673 - 345 WP_078274937.1 hypothetical protein -
LP129_RS11790 (LP129_11695) 2325674..2326480 - 807 WP_112741850.1 hypothetical protein -
LP129_RS11795 (LP129_11700) 2326534..2326971 - 438 WP_162860346.1 hypothetical protein -
LP129_RS11800 (LP129_11705) 2326905..2327237 - 333 WP_112741848.1 hypothetical protein -
LP129_RS11805 (LP129_11710) 2327234..2328205 - 972 WP_112741847.1 phage tail tape measure protein -
LP129_RS11810 (LP129_11715) 2328281..2328688 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP129_RS11815 (LP129_11720) 2328751..2328939 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP129_RS11820 (LP129_11725) 2329082..2329297 - 216 WP_078274941.1 hypothetical protein -
LP129_RS11825 (LP129_11730) 2329299..2329898 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP129_RS11830 (LP129_11735) 2330005..2330211 - 207 WP_264676102.1 DNA-binding protein -
LP129_RS11835 (LP129_11740) 2330334..2330678 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP129_RS11840 (LP129_11745) 2330722..2331474 - 753 WP_078274945.1 hypothetical protein -
LP129_RS11845 (LP129_11750) 2331552..2331752 - 201 WP_264676324.1 hypothetical protein -
LP129_RS11850 (LP129_11755) 2331761..2331952 - 192 WP_264676101.1 DNA-binding protein -
LP129_RS11855 (LP129_11760) 2331967..2332176 - 210 WP_078274960.1 hypothetical protein -
LP129_RS11860 (LP129_11765) 2332341..2332640 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP129_RS11865 (LP129_11770) 2332835..2333122 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP129_RS11870 (LP129_11775) 2333119..2333538 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2323229..2333538 10309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226137 WP_078274940.1 NZ_CP087781:c2328939-2328751 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226137 NZ_CP122315:3488244-3488618 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226137 WP_112741846.1 NZ_CP087781:c2328688-2328281 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226137 NZ_CP122315:3487787-3488155 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References