Detailed information of TA system TA226135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1449108..1449765
• Replicon: chromosome
• Accession: NZ_CP087781
• Organism: Moraxella bovis strain SAM57978

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP129_RS07645
• Protein ID: WP_264676287.1
• Coordinates: 1449583..1449765 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP129_RS07640
• Protein ID: WP_264676286.1
• Coordinates: 1449108..1449521 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP129_RS07595 (LP129_07535)	1444783..1445391	+	609	WP_078273440.1	hypothetical protein	-
LP129_RS07600 (LP129_07540)	1445388..1445795	+	408	WP_112742083.1	VRR-NUC domain-containing protein	-
LP129_RS07605 (LP129_07545)	1445792..1446070	+	279	WP_264689775.1	hypothetical protein	-
LP129_RS07610 (LP129_07550)	1446117..1446314	-	198	WP_264682993.1	ribbon-helix-helix domain-containing protein	-
LP129_RS07615 (LP129_07555)	1446976..1447653	+	678	WP_264682991.1	Bro-N domain-containing protein	-
LP129_RS07620 (LP129_07560)	1447717..1448202	+	486	WP_078273444.1	recombination protein NinB	-
LP129_RS07625 (LP129_07565)	1448339..1448494	+	156	WP_264676283.1	hypothetical protein	-
LP129_RS07630 (LP129_07570)	1448491..1448712	+	222	WP_264676284.1	DUF3310 domain-containing protein	-
LP129_RS07635 (LP129_07575)	1448696..1449097	+	402	WP_264676285.1	antiterminator Q family protein	-
LP129_RS07640 (LP129_07580)	1449108..1449521	-	414	WP_264676286.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP129_RS07645 (LP129_07585)	1449583..1449765	-	183	WP_264676287.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP129_RS07650 (LP129_07590)	1450165..1450869	+	705	WP_264676288.1	BRO family protein	-
LP129_RS07655 (LP129_07595)	1451296..1451496	-	201	WP_264676289.1	helix-turn-helix domain-containing protein	-
LP129_RS07660 (LP129_07600)	1451533..1451742	-	210	WP_264676290.1	hypothetical protein	-
LP129_RS07665 (LP129_07605)	1451856..1452395	+	540	WP_264695558.1	terminase small subunit	-
LP129_RS07670 (LP129_07610)	1452395..1453777	+	1383	WP_264695560.1	phage terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1428961..1469812	40851

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-79)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6761.81 Da
• Isoelectric Point: 10.7622

>T226135 WP_264676287.1 NZ_CP087781:c1449765-1449583 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Nucleotide

• Length: 183 bp

>T226135 NZ_CP122315:c3057083-3056796 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15339.53 Da
• Isoelectric Point: 4.7523

>AT226135 WP_264676286.1 NZ_CP087781:c1449521-1449108 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Nucleotide

• Length: 414 bp

>AT226135 NZ_CP122315:c3057322-3057083 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA