Detailed information of TA system TA226133

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1099329..1099881
• Replicon: chromosome
• Accession: NZ_CP087781
• Organism: Moraxella bovis strain SAM57978

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP129_RS05760
• Protein ID: WP_029102268.1
• Coordinates: 1099603..1099881 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP129_RS05755
• Protein ID: WP_078273473.1
• Coordinates: 1099329..1099616 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP129_RS05740 (LP129_05705)	1094764..1095813	+	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP129_RS05745 (LP129_05710)	1095892..1097391	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP129_RS05750 (LP129_05715)	1097589..1099319	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP129_RS05755 (LP129_05720)	1099329..1099616	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP129_RS05760 (LP129_05725)	1099603..1099881	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP129_RS05765 (LP129_05730)	1099976..1100632	-	657	WP_078273472.1	YqiJ family protein	-
LP129_RS05770 (LP129_05735)	1100832..1101497	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP129_RS05775 (LP129_05740)	1101710..1102000	-	291	WP_264676229.1	hypothetical protein	-
LP129_RS05780 (LP129_05745)	1101993..1102508	-	516	WP_115369660.1	hypothetical protein	-
LP129_RS05785 (LP129_05750)	1102656..1103006	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP129_RS05790 (LP129_05755)	1103118..1103894	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226133 WP_029102268.1 NZ_CP087781:c1099881-1099603 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226133 NZ_CP122315:2920736-2920912 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226133 WP_078273473.1 NZ_CP087781:c1099616-1099329 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226133 NZ_CP122315:2920958-2921374 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3